{"id":19010,"date":"2019-01-30T09:55:07","date_gmt":"2019-01-30T09:55:07","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=19010"},"modified":"2019-01-30T09:59:02","modified_gmt":"2019-01-30T09:59:02","slug":"a-compromised-paraventricular-nucleus-within-a-dysfunctional-hypothalamus-a-novel-neuroinflammatory-paradigm-for-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/a-compromised-paraventricular-nucleus-within-a-dysfunctional-hypothalamus-a-novel-neuroinflammatory-paradigm-for-me-cfs\/","title":{"rendered":"A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME\/CFS"},"content":{"rendered":"\r\n

A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME\/CFS<\/a>, by\u00a0Angus Mackay, Warren P Tate\u00a0in<\/span> International Journal of Immunopathology and Pharmacology<\/em> Vol: 32 [published online: December 6, 2018]<\/h3>\r\n

 <\/p>\r\n

Article abstract:<\/strong>\u00a0
\"\"<\/a>A neuroinflammatory paradigm is presented to help explain the pathophysiology of myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS).<\/p>\r\n

The hypothalamic paraventricular nucleus<\/a> (PVN) is responsible for absorbing and processing multiple, incoming and convergent \u2018stress\u2019 signals, and if this cluster of neurons were affected (by neuroinflammation), the ongoing hypersensitivity of ME\/CFS patients to a wide range of \u2018stressors\u2019 could be explained.<\/p>\r\n

Neuroinflammation that was chronic and fluctuating, as \u2018inflammatory-marker\u2019 studies support, could reflect a dynamic change in the hypothalamic PVN\u2019s threshold for managing incoming \u2018stress\u2019 signals. This may not only be a mechanism underpinning the characteristic feature of ME\/CFS, post-exertional malaise, and its associated debilitating relapses, but could also be responsible for mediating the long-term perpetuation of the disease.<\/p>\r\n

Triggers (sustained physiological \u2018stressors\u2019) of ME\/CFS, such as a particular viral infection, toxin exposure, or a traumatic event, could also target the hypothalamic PVN, a potentially vulnerable site in the brains of ME\/CFS susceptible people, and disruption of its complex neural circuitry could account for the onset of ME\/CFS.<\/p>\r\n

In common with the different \u2018endogenous factors\u2019<\/a> identified in the early \u2018neuroinflammatory\u2019 stages of the \u2018neurodegenerative\u2019 diseases, an as yet, unidentified factor within the brains and central nervous system (CNS) of ME\/CFS patients might induce both an initial and then sustained \u2018neuroinflammatory\u2019 response by its \u2018innate immune system\u2019.\u00a0 Positron emission tomography\/magnetic resonance imaging has reinforced evidence of glial cell activation centred on the brain\u2019s limbic system of ME\/CFS patients.<\/p>\r\n

Neuroinflammation causing dysfunction of the limbic system<\/a> and its hypothalamus together with a consequently disrupted autonomic nervous system could account for the diverse range of symptoms in ME\/CFS relating, in particular to fatigue, mood, cognitive function, sleep, thermostatic control, gastrointestinal disturbance, and hypotension.<\/p>\r\n","protected":false},"excerpt":{"rendered":"

A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME\/CFS, by\u00a0Angus Mackay, Warren P Tate\u00a0in International Journal of Immunopathology and Pharmacology Vol: 32 [published online: December 6, 2018]   Article abstract:\u00a0A neuroinflammatory paradigm is presented to … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4844,4843,2574,1174,705,4117],"class_list":["post-19010","post","type-post","status-publish","format-standard","hentry","category-news","tag-angus-mackay","tag-dysfunctional-paraventricular-nucleus","tag-hypothalamus","tag-limbic-system","tag-neuroinflammation","tag-prof-warren-tate"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-4WC","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19010","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=19010"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19010\/revisions"}],"predecessor-version":[{"id":19446,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19010\/revisions\/19446"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=19010"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=19010"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=19010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}