{"id":19022,"date":"2019-01-03T08:21:13","date_gmt":"2019-01-03T08:21:13","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=19022"},"modified":"2019-01-03T08:21:13","modified_gmt":"2019-01-03T08:21:13","slug":"peak-oxygen-uptake-in-cfs-me-a-meta-analysis","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/peak-oxygen-uptake-in-cfs-me-a-meta-analysis\/","title":{"rendered":"Peak oxygen uptake in CFS\/ME: a meta-analysis"},"content":{"rendered":"

Peak Oxygen Uptake in Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis: A Meta-Analysis<\/a> by John D Franklin, Greg\u00a0Atkinson, Janet M Atkinson, Alan M\u00a0Batterham in<\/span> International Journal of Sports Medicine<\/em>,\u00a0Dec 2018<\/p>\n

Review abstract:<\/strong><\/p>\n

\"\"<\/a>To evaluate the magnitude of the difference in VO2peak<\/a> between patients with Chronic Fatigue Syndrome\/ Myalgic Encephalomyelitis (CFS\/ME) and apparently healthy controls, 7 databases (Cochrane, PubMed, PsycINFO, Web of Knowledge, Embase, Scopus, Medline) were searched for articles published up to March 2018.<\/p>\n

Search terms included ‘chronic fatigue syndrom*’AND (‘peak’ OR ‘maxim*’ OR ‘max’) AND (‘oxygen uptake’ OR ‘oxygen consumption’ OR ‘VO2peak’ or ‘VO2max’. Eligibility criteria were adults>18\u2009y with clinically diagnosed CFS\/ME, with VO2peak measured in a maximal test and compared against an apparently healthy control group.<\/p>\n

The methodological quality of included studies was assessed using a modified Systematic Appraisal of Quality for Observational Research critical appraisal framework. A random effects meta-analysis was conducted on 32 cross-sectional studies (effects). Pooled mean VO2peak was 5.2 (95% CI: 3.8-6.6) ml.kg-1min-1 lower in CFS\/ME patients vs. healthy controls. Between-study variability (Tau) was 3.4 (1.5-4.5) ml.kg-1min-1 indicating substantial heterogeneity. The 95% prediction interval was -1.9 to 12.2\u2009ml.kg-1min-1.<\/p>\n

The probability that the effect in a future study would be>the minimum clinically important difference of 1.1\u2009ml.kg-1min-1 (in favour of controls) was 0.88 – likely to be clinically relevant.<\/p>\n

Synthesis of the available evidence indicates that CFS\/ME patients have a substantially reduced VO2peak compared to controls.<\/p>\n","protected":false},"excerpt":{"rendered":"

Peak Oxygen Uptake in Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis: A Meta-Analysis by John D Franklin, Greg\u00a0Atkinson, Janet M Atkinson, Alan M\u00a0Batterham in International Journal of Sports Medicine,\u00a0Dec 2018 Review abstract: To evaluate the magnitude of the difference in VO2peak between patients … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4773,4770,4771,4772,4769,4768,714,4767],"class_list":["post-19022","post","type-post","status-publish","format-standard","hentry","category-news","tag-alan-m-batterham","tag-greg-atkinson","tag-janet-m-atkinson","tag-john-d-franklin","tag-maximal-oxygen-uptake","tag-peak-oxygen-uptake","tag-vo2","tag-vo2peak"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-4WO","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=19022"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19022\/revisions"}],"predecessor-version":[{"id":19044,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19022\/revisions\/19044"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=19022"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=19022"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=19022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}