{"id":19069,"date":"2019-01-09T08:13:19","date_gmt":"2019-01-09T08:13:19","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=19069"},"modified":"2019-01-09T08:13:19","modified_gmt":"2019-01-09T08:13:19","slug":"a-systematic-review-of-enteric-dysbiosis-in-cfs-me","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/a-systematic-review-of-enteric-dysbiosis-in-cfs-me\/","title":{"rendered":"A systematic review of enteric dysbiosis in CFS\/ME"},"content":{"rendered":"

A systematic review of enteric dysbiosis in chronic fatigue syndrome\/myalgic encephalomyelitis<\/a>, by S\u00a0Du Preez, M\u00a0Corbitt, H\u00a0Cabanas, N\u00a0Eaton, D Staines and S\u00a0Marshall-Gradisnik in<\/span> Systematic Reviews<\/em> 2018 7:241 [Published: 20\u00a0December\u00a02018]<\/h3>\n

Review abstract:<\/strong><\/p>\n

Background:<\/strong>
\n\"\"<\/a>Chronic fatigue syndrome or myalgic encephalomyelitis (CFS\/ME) is an illness characterised by profound and pervasive fatigue in addition to a heterogeneous constellation of symptoms. The aetiology of this condition remains unknown; however, it has been previously suggested that enteric dysbiosis<\/a> is implicated in the pathogenesis of CFS\/ME.<\/p>\n

This review examines the evidence currently available for the presence of abnormal microbial ecology in CFS\/ME in comparison to healthy controls, with one exception being probiotic-supplemented CFS\/ME patients, and whether the composition of the microbiome plays a role in symptom causation.<\/p>\n

Methods:<\/strong>
\nEMBASE, Medline (via EBSCOhost), Pubmed and Scopus were systematically searched from 1994 to March 2018. All studies that investigated the gut microbiome composition of CFS\/ME patients were initially included prior to the application of specific exclusion criteria. The association between these findings and patient-centred outcomes (fatigue, quality of life, gastrointestinal symptoms, psychological wellbeing) are also reported.<\/p>\n

Results:<\/strong>
\nSeven studies that met the inclusion criteria were included in the review. The microbiome composition of CFS\/ME patients was compared with healthy controls, with the exception of one study that compared to probiotic-supplemented CFS\/ME patients. Differences were reported in each study; however, only three were considered statistically significant, and the findings across all studies were inconsistent. The quality of the studies included in this review scored between poor (<\u200954%), fair (54\u201372%) and good (94\u2013100%) using the Downs and Black checklist.<\/p>\n

Conclusions:<\/strong>
\nThere is currently insufficient evidence for enteric dysbiosis playing a significant role in the pathomechanism of CFS\/ME. Recommendations for future research in this field include the use of consistent criteria for the diagnosis of CFS\/ME, reduction of confounding variables by controlling factors that influence microbiome composition prior to sample collection and including more severe cases of CFS\/ME.<\/p>\n","protected":false},"excerpt":{"rendered":"

A systematic review of enteric dysbiosis in chronic fatigue syndrome\/myalgic encephalomyelitis, by S\u00a0Du Preez, M\u00a0Corbitt, H\u00a0Cabanas, N\u00a0Eaton, D Staines and S\u00a0Marshall-Gradisnik in Systematic Reviews 2018 7:241 [Published: 20\u00a0December\u00a02018] Review abstract: Background: Chronic fatigue syndrome or myalgic encephalomyelitis (CFS\/ME) is an … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[1249,4781,1325,4308,4224,4782,4307,2676,4450],"class_list":["post-19069","post","type-post","status-publish","format-standard","hentry","category-news","tag-dr-sonya-marshall-gradisnik","tag-enteric-dysbiosis","tag-gut-microbiome","tag-helene-cabanas","tag-matthew-corbitt","tag-microbial-imbalance","tag-natalie-eaton","tag-prof-donald-staines","tag-s-du-preez"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-4Xz","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19069","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=19069"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19069\/revisions"}],"predecessor-version":[{"id":19176,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19069\/revisions\/19176"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=19069"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=19069"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=19069"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}