{"id":19097,"date":"2019-01-16T08:48:21","date_gmt":"2019-01-16T08:48:21","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=19097"},"modified":"2019-02-10T10:48:11","modified_gmt":"2019-02-10T10:48:11","slug":"prospective-biomarkers-from-plasma-metabolomics-of-me-cfs-implicate-redox-imbalance-in-disease-symptomatology","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/prospective-biomarkers-from-plasma-metabolomics-of-me-cfs-implicate-redox-imbalance-in-disease-symptomatology\/","title":{"rendered":"Prospective biomarkers from plasma metabolomics of ME\/CFS implicate redox imbalance in disease symptomatology"},"content":{"rendered":"

Prospective biomarkers from plasma metabolomics of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome\u00a0implicate Redox imbalance in disease symptomatology<\/a>, by Arnaud Germain, David Ruppert, Susan M. Levine and Maureen R. Hanson in<\/span> Metabolites<\/em> 2018, 8(4), 90 [Published 6 Dec 2018]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong>
\nMyalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) is a disease of enigmatic origin with no established cure. Its constellation of symptoms has silently ruined the lives of millions of people around the world. A plethora of hypotheses have been vainly investigated over the past few decades, so that the biological basis of this debilitating condition remains a mystery.<\/p>\n

\"\"<\/a>In this study, we investigate whether there is a disturbance in homeostasis of metabolic<\/a> networks in the plasma of a female 32-patient cohort compared to 19 healthy female controls.<\/p>\n

Extensive analysis of the 832-metabolite dataset generated by Metabolon\u00ae, covering eight biological classes, generated important insight into metabolic disruptions that occur in ME\/CFS. We report on 14 metabolites with differences in abundance, allowing us to develop a theory of broad redox imbalance<\/a> in ME\/CFS patients, which is consistent with findings of prior work in the ME\/CFS field.<\/p>\n

Moreover, exploration of enrichment analysis using www.MetaboAnalyst.ca <\/a>provides information concerning similarities between metabolite disruptions in ME\/CFS and those that occur in other diseases, while its biomarker analysis unit yielded prospective plasma biomarkers for ME\/CFS. This work contributes key elements to the development of ME\/CFS diagnostics, a crucial step required for discovering a therapy for any disease of unknown origin.<\/p>\n

Comment<\/strong>: Metabolomics Study Suggests Chronic Fatigue Syndrome May Be Oxidative Stress\/Low Oxygen Disease<\/a><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Prospective biomarkers from plasma metabolomics of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome\u00a0implicate Redox imbalance in disease symptomatology, by Arnaud Germain, David Ruppert, Susan M. Levine and Maureen R. Hanson in Metabolites 2018, 8(4), 90 [Published 6 Dec 2018]   Research abstract: Myalgic … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3398,726,3397,2859,2530,3383,4811],"class_list":["post-19097","post","type-post","status-publish","format-standard","hentry","category-news","tag-arnaud-germain","tag-biomarkers","tag-david-ruppert","tag-dr-maureen-hanson","tag-dr-susan-levine","tag-metabolic-dysfunction","tag-redox-imbalance"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-4Y1","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19097","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=19097"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19097\/revisions"}],"predecessor-version":[{"id":19599,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19097\/revisions\/19599"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=19097"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=19097"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=19097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}