{"id":19184,"date":"2019-01-11T05:51:31","date_gmt":"2019-01-11T05:51:31","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=19184"},"modified":"2019-01-11T05:52:09","modified_gmt":"2019-01-11T05:52:09","slug":"evidence-of-widespread-metabolite-abnormalities-in-me-cfs-assessment-with-whole-brain-magnetic-resonance-spectroscopy","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/evidence-of-widespread-metabolite-abnormalities-in-me-cfs-assessment-with-whole-brain-magnetic-resonance-spectroscopy\/","title":{"rendered":"Evidence of widespread metabolite abnormalities in ME\/CFS: assessment with whole-brain magnetic resonance spectroscopy"},"content":{"rendered":"

Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis\/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy<\/a>, by Christina Mueller, Joanne C Lin, Sulaiman Sheriff, Andrew A Maudsley, Jarred W. Younger\u00a0in<\/span> Brain Imaging and Behavior<\/em> 2019: pp 1\u201311 [First Online: 07 January 2019]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

\"\"<\/a>Previous neuroimaging studies have detected markers of neuroinflammation<\/a> in patients with Myalgic Encephalomyelitis\/ Chronic Fatigue Syndrome (ME\/CFS). Magnetic Resonance Spectroscopy<\/a> (MRS) is suitable for measuring brain metabolites<\/a> linked to inflammation, but has only been applied to discrete regions of interest in ME\/CFS.<\/p>\n

We extended the MRS analysis of ME\/CFS by capturing multi-voxel information across the entire brain. Additionally, we tested whether MRS-derived brain temperature is elevated in ME\/CFS patients.<\/p>\n

Fifteen women with ME\/CFS and 15 age- and gender-matched healthy controls completed fatigue and mood symptom questionnaires and whole-brain echo-planar spectroscopic imaging (EPSI). Choline (CHO), myo-inositol (MI), lactate (LAC), and N-acetylaspartate (NAA) were quantified in 47 regions, expressed as ratios over creatine (CR), and compared between ME\/CFS patients and controls using independent-samples t-tests. Brain
\ntemperature was similarly tested between groups.<\/p>\n

Significant between-group differences were detected in several regions, most notably elevated CHO\/CR in the left anterior cingulate (p\u2009<\u20090.001). Metabolite ratios in seven regions were correlated with fatigue (p\u2009<0.05). ME\/CFS patients had increased temperature in the right insula, putamen, frontal cortex, thalamus, and the cerebellum (all p\u2009<\u20090.05), which was not attributable to increased body temperature or differences in cerebral perfusion. Brain temperature increases converged with elevated LAC\/CR in the right insula, right thalamus, and cerebellum (all p\u2009<\u20090.05).<\/p>\n

We report metabolite and temperature abnormalities in ME\/CFS patients in widely distributed regions. Our findings may indicate that ME\/CFS involves neuroinflammation.<\/p>\n","protected":false},"excerpt":{"rendered":"

Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis\/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy, by Christina Mueller, Joanne C Lin, Sulaiman Sheriff, Andrew A Maudsley, Jarred W. Younger\u00a0in Brain Imaging and Behavior 2019: pp 1\u201311 [First Online: 07 … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4787,4790,4792,4788,1960,4786,3476,4789,4791,4785],"class_list":["post-19184","post","type-post","status-publish","format-standard","hentry","category-news","tag-andrew-a-maudsley","tag-brain-metabolism","tag-brain-temperature","tag-christina-mueller","tag-dr-jarred-younger","tag-joanne-c-lin","tag-magnetic-resonance-spectroscopy","tag-mrs","tag-neuroimflammation","tag-sulaiman-sheriff"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-4Zq","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19184","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=19184"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19184\/revisions"}],"predecessor-version":[{"id":19201,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19184\/revisions\/19201"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=19184"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=19184"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=19184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}