{"id":19539,"date":"2019-02-08T09:03:03","date_gmt":"2019-02-08T09:03:03","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=19539"},"modified":"2019-02-08T09:04:06","modified_gmt":"2019-02-08T09:04:06","slug":"impairments-in-cognitive-performance-in-cfs-are-common-not-related-to-co-morbid-depression-but-do-associate-with-autonomic-dysfunction","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/impairments-in-cognitive-performance-in-cfs-are-common-not-related-to-co-morbid-depression-but-do-associate-with-autonomic-dysfunction\/","title":{"rendered":"Impairments in cognitive performance in CFS are common, not related to co-morbid depression but do associate with autonomic dysfunction"},"content":{"rendered":"

Impairments in cognitive performance in chronic fatigue syndrome are common, not related to co-morbid depression but do associate with autonomic dysfunction<\/a>, by
\nLucy J Robinson, Peter Gallagher, Stuart Watson, Ruth Pearce, Andreas Finkelmeyer, Laura Maclachlan, Julia L Newton in<\/span> \u00a0PLoS ONE<\/em> 14 (2)\u00a0[Published: February 5, 2019]<\/h3>\n

Research abstract:<\/strong><\/p>\n

Objectives:
\n\"\"<\/a>To explore cognitive performance in chronic fatigue syndrome (CFS) examining two cohorts. To establish findings associated with CFS and those related to co-morbid depression or autonomic dysfunction<\/a>.<\/p>\n

Methods:
\nIdentification and recruitment of participants was identical in both phases, all CFS patients fulfilled Fukuda criteria. In Phase 1 (n=48) we explored cognitive function in a heterogeneous cohort of CFS patients, investigating links with depressive symptoms (HADS). In phase 2 (n=51 CFS & n=20 controls) participants with co-morbid major depression were excluded (SCID). Furthermore, we investigated relationships between
\ncognitive performance and heart rate variability (HRV).<\/p>\n

Results:
\nCognitive performance in unselected CFS patients is in average range on most measures. However, 0-23% of the CFS sample fell below the 5thpercentile. Negative correlations occurred between depressive symptoms (HAD-S) with Digit-Symbol-Coding (r=-.507, p=.006) and TMT-A (r=-.382, p=.049). In CFS without depression, impairments of cognitive performance remained with significant differences in indices of psychomotor speed (TMT-A: p=0.027; digit-symbol substitution: p=0.004; digit-symbol copy: p=0.007; scanning: p=.034) Stroop test suggested differences due to processing speed rather than inhibition.<\/p>\n

Both cohorts confirmed relationships between cognitive performance and HRV (digit-symbol copy (r=.330, p=.018), digit-symbol substitution (r=.313, p=.025), colour-naming trials Stroop task (r=.279, p=.050).<\/p>\n

Conclusion:
\nCognitive difficulties in CFS may not be as broad as suggested and may be restricted to slowing in basic processing speed<\/a>. While depressive symptoms can be associated with impairments, co-morbidity with major depression is not itself responsible for reductions in cognitive performance. Impaired autonomic control<\/a> of heart-rate associates with
\nreductions in basic processing speed.<\/p>\n

Graphic from pngtree.com<\/em><\/h5>\n","protected":false},"excerpt":{"rendered":"

Impairments in cognitive performance in chronic fatigue syndrome are common, not related to co-morbid depression but do associate with autonomic dysfunction, by Lucy J Robinson, Peter Gallagher, Stuart Watson, Ruth Pearce, Andreas Finkelmeyer, Laura Maclachlan, Julia L Newton in \u00a0PLoS … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[33,321,291,3249,2104,4051,2147,420,4862,4050],"class_list":["post-19539","post","type-post","status-publish","format-standard","hentry","category-news","tag-cognitive-dysfunction","tag-depression","tag-heart-rate-variability","tag-laura-maclachlan","tag-lucy-j-robinson","tag-peter-gallagher","tag-prof-andreas-finkelmeyer","tag-prof-julia-newton","tag-ruth-pearce","tag-stuart-watson"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-559","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19539","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=19539"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19539\/revisions"}],"predecessor-version":[{"id":19581,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/19539\/revisions\/19581"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=19539"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=19539"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=19539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}