{"id":20019,"date":"2019-05-20T07:50:02","date_gmt":"2019-05-20T07:50:02","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=20019"},"modified":"2019-05-20T07:50:32","modified_gmt":"2019-05-20T07:50:32","slug":"treatment-avenues-in-me-cfs-a-split-gender-pharmacogenomic-study-of-gene-expression","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/treatment-avenues-in-me-cfs-a-split-gender-pharmacogenomic-study-of-gene-expression\/","title":{"rendered":"Treatment avenues in ME\/CFS: a split-gender pharmacogenomic study of gene-expression"},"content":{"rendered":"

Treatment avenues in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: a split-gender pharmacogenomic study of gene-expression modules<\/a>, by Mary G Jeffrey, Lubov Nathanson, Kristina Aenlle, Zachary M Barnes, Mirza Baig, Gordon Broderick, Nancy G Klimas, Mary Ann Fletcher, Travis JA Craddock in<\/span> Clinical Therapeutics<\/em> vol 41, issue 5, May 2019, pages 815-835.e6 [https:\/\/doi.org\/10.1016\/j.clinthera.2019.01.011]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

\"doctor<\/a>Purpose:<\/strong>
\nMyalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a debilitating multisymptom illness impacting up to 1 million people in the United States. As the pathogenesis<\/a> and etiology<\/a> of this complex condition are unclear, prospective treatments are limited. Identifying US Food and Drug Administration-approved drugs that may be repositioned as treatments for ME\/CFS may offer a rapid and cost-effective solution.<\/p>\n

Methods:<\/strong>
\nHere we used gene-expression<\/a> data from 33 patients with Fukuda-defined ME\/CFS (23 females, 10 males) and 21 healthy demographically comparable controls (15 females, 6 males) to identify differential expression of predefined gene-module sets based on nonparametric statistics.<\/p>\n

Differentially expressed gene modules were then annotated via over-representation analysis using the Consensus Pathway database<\/a>.<\/p>\n

Differentially expressed modules were then regressed onto measures of fatigue and cross-referenced with drug atlas and pharmacogenomics databases to identify putative treatment agents.<\/p>\n

Findings:<\/strong>
\nThe top 1% of modules identified in males indicated small effect sizes in modules associated with immune regulation and mitochondrial dysfunction. In females, modules identified included those related to immune factors and cardiac\/blood factors, returning effect sizes ranging from very small to intermediate (0.147<Cohen delta<0.532).<\/p>\n

Regression analysis indicated that B-cell receptors, T-cell receptors, tumor necrosis factor alpha, transforming growth factor beta, and metabolic and cardiac modules were strongly correlated with multiple composite measures of fatigue. Cross-referencing identified genes with pharmacogenomics data indicated immunosuppressant<\/a>s as potential treatments of ME\/CFS symptoms.<\/p>\n

Implications:<\/strong>
\nThe findings from our analysis suggest that ME\/CFS symptoms are perpetuated by immune dysregulation<\/a> that may be approached via immune modulation-based treatment strategies.<\/p>\n

Read full article<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Treatment avenues in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: a split-gender pharmacogenomic study of gene-expression modules, by Mary G Jeffrey, Lubov Nathanson, Kristina Aenlle, Zachary M Barnes, Mirza Baig, Gordon Broderick, Nancy G Klimas, Mary Ann Fletcher, Travis JA Craddock in Clinical … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[5055,1878,5053,4914,831,1064,5057,4546,3631,5056,5058,5054,4915,2957,3632],"class_list":["post-20019","post","type-post","status-publish","format-standard","hentry","category-news","tag-bioinformatics","tag-dr-nancy-klimas","tag-drug-repositioning","tag-gordon-broderick","tag-immune-dysregulation","tag-immunosuppressants","tag-kistina-aenlle","tag-lubov-nathanson","tag-mary-ann-fletcher","tag-mary-g-jeffrey","tag-mirza-baig","tag-pharmacogenomics","tag-travis-ja-craddock","tag-treatments","tag-zachary-barnes"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-5cT","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/20019","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=20019"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/20019\/revisions"}],"predecessor-version":[{"id":21175,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/20019\/revisions\/21175"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=20019"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=20019"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=20019"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}