{"id":20113,"date":"2019-03-28T07:49:31","date_gmt":"2019-03-28T07:49:31","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=20113"},"modified":"2019-03-28T07:49:31","modified_gmt":"2019-03-28T07:49:31","slug":"diagnostic-sensitivity-of-2-day-cardiopulmonary-exercise-testing-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/diagnostic-sensitivity-of-2-day-cardiopulmonary-exercise-testing-in-me-cfs\/","title":{"rendered":"Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in ME\/CFS"},"content":{"rendered":"

Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome<\/a>, by Maximillian J Nelson,\u00a0 Jonathan D Buckley, Rebecca L Thomson, Daniel Clark, Richard Kwiatek and Kade Davison in Journal of Translational Medicine 2019 17:80 [Published: 14 March 2019]<\/h3>\n

Research abstract:<\/strong><\/p>\n

\"\"<\/a>BACKGROUND: There are no known objective biomarkers to assist with the diagnosis of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS). A small number of studies have shown that ME\/CFS patients exhibit an earlier onset of ventilatory threshold (VT) on the second of two cardiopulmonary exercise tests (CPET) performed on consecutive days. However, cut-off values which could be used to differentiate between ME\/CFS patients have not been established.<\/p>\n

METHODS: 16 ME\/CFS patients and 10 healthy controls underwent CPET on a cycle-ergometer on 2-consecutive days. Heart rate (HR), ventilation, ratings of perceived exertion (RPE) and work rate (WR) were assessed on both days.<\/p>\n

RESULTS: WR at VT decreased from day 1 to day 2 and by a greater magnitude in ME\/CFS patients (p\u2009<\u20090.01 group\u2009\u00d7\u2009time interaction). No interaction effects were found for any other parameters. ROC curve analysis of the percentage change in WR at VT revealed decreases of – 6.3% to -\u20099.8% provided optimal sensitivity and specificity respectively for distinguishing between patients with ME\/CFS and controls.<\/p>\n

CONCLUSION: The decrease in WR at VT of 6.3-9.8% on the 2nd day of consecutive-day CPET may represent an objective biomarker that can be used to assist with the diagnosis of ME\/CFS.<\/p>\n","protected":false},"excerpt":{"rendered":"

Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome, by Maximillian J Nelson,\u00a0 Jonathan D Buckley, Rebecca L Thomson, Daniel Clark, Richard Kwiatek and Kade Davison in Journal of Translational Medicine 2019 17:80 [Published: 14 March 2019] … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3049,4170,679,4938,614,4940,4937,4941,4939,3876],"class_list":["post-20113","post","type-post","status-publish","format-standard","hentry","category-news","tag-2-day-cpet","tag-biomarker","tag-cardiopulmonary-exercise-tests","tag-daniel-clark","tag-diagnostic-marker","tag-jonathan-d-buckley","tag-kade-davison","tag-maximillian-j-nelson","tag-rebecca-l-thomson","tag-richard-kwiatek"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-5ep","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/20113","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=20113"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/20113\/revisions"}],"predecessor-version":[{"id":20282,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/20113\/revisions\/20282"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=20113"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=20113"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=20113"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}