{"id":20377,"date":"2019-04-17T06:56:25","date_gmt":"2019-04-17T06:56:25","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=20377"},"modified":"2019-04-17T06:56:25","modified_gmt":"2019-04-17T06:56:25","slug":"cellular-immune-function-in-me-cfs-increased-mait-cell-frequency","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/cellular-immune-function-in-me-cfs-increased-mait-cell-frequency\/","title":{"rendered":"Cellular immune function in ME\/CFS: increased MAIT cell frequency"},"content":{"rendered":"

Cellular immune function in myalgic encephalomyelitis\/chronic\u00a0fatigue syndrome (ME\/CFS),<\/a> by Jacqueline M Cliff, Elizabeth C King, Ji-Sook Lee, Nuno Sepulveda, Asia-Sofia Wolf, Caroline Kingdon, Erinna Bowman, Hazel M. Dockrell, Luis C. Nacul, Eliana Lacerda, Eleanor Riley in<\/span> Front. Immunol<\/em>., 16 April 2019, https:\/\/doi.org\/10.3389\/fimmu.2019.00796<\/h3>\n

Research abstract:<\/strong><\/h3>\n
\"\"<\/a>

Lead author Dr Jackie Cliff<\/p><\/div>\n

Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a debilitating condition with unknown aetiology, unclear pathophysiology and with no diagnostic test or biomarker available. Many patients report their ME\/CFS began after an acute infection, and subsequent increased
\nfrequency of infections, such as colds or influenza, is common. These factors imply an altered immunological status exists in ME\/CFS, in at least a proportion of patients, yet previous studies of peripheral
\nimmunity have been discrepant and inconclusive.<\/p>\n

The UK ME\/CFS Biobank, which has collected blood samples from nearly 300 clinically-confirmed ME\/CFS patients, enables large-scale studies of immunological function in phenotypically well-characterised participants. In this study, herpes virus serological status and T cell, B cell, NK cell and monocyte populations were investigated in 251 ME\/CFS patients, including 54 who were severely affected, and compared with those from 107 healthy participants and with 46 patients with Multiple Sclerosis. There were no differences in seroprevalence for six human herpes viruses between ME\/CFS and healthy controls, although seroprevalence for the Epstein-Barr virus was higher in multiple sclerosis patients.<\/p>\n

Contrary to previous reports, no significant differences were observed in NK cell numbers, subtype proportions or in vitro responsiveness between ME\/CFS patients and healthy control participants. In contrast, the T cell compartment was altered in ME\/CFS, with reduced proportions of effector memory CD8+ T cells and of\u00a0intermediately differentiated CD8+ T cells in ME\/CFS. Conversely, there as a significantly increased proportion of mucosal associated invariant\u00a0cells (MAIT) cells, especially in severely affected ME\/CFS patients.<\/p>\n

These abnormalities demonstrate that an altered immunological state does exist in ME\/CFS, particularly in severely affected people. This may simply reflect ongoing or recent infection, or may indicate future increased susceptibility to infection. Longitudinal studies of ME\/CFS patients are needed to help to determine cause and effect and thus any
\npotential benefits of immuno-modulatory treatments for ME\/CFS.<\/p>\n

Lay summary<\/strong>: Increased MAIT cell frequency in ME\/CFS<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Cellular immune function in myalgic encephalomyelitis\/chronic\u00a0fatigue syndrome (ME\/CFS), by Jacqueline M Cliff, Elizabeth C King, Ji-Sook Lee, Nuno Sepulveda, Asia-Sofia Wolf, Caroline Kingdon, Erinna Bowman, Hazel M. Dockrell, Luis C. Nacul, Eliana Lacerda, Eleanor Riley in Front. Immunol., 16 April … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4987,4717,2502,3425,4984,655,4973,1172,4813,4985,4981,4983,722,691,4986,4982],"class_list":["post-20377","post","type-post","status-publish","format-standard","hentry","category-news","tag-asia-sofia-wolf","tag-caroline-kingdon","tag-cd8-t-cells","tag-dr-luis-nacul","tag-elizabeth-c-king","tag-erinna-bowman","tag-hazel-m-dockrell","tag-immune-activation","tag-jacqueline-m-cliff","tag-ji-sook-lee","tag-mait-cells","tag-mucosal-associated-invariant-cells","tag-natural-killer-cells","tag-nk-cells","tag-nuno-sepulveda","tag-t-cell-activation"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-5iF","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/20377","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=20377"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/20377\/revisions"}],"predecessor-version":[{"id":20561,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/20377\/revisions\/20561"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=20377"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=20377"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=20377"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}