{"id":20529,"date":"2019-04-15T07:11:48","date_gmt":"2019-04-15T07:11:48","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=20529"},"modified":"2019-04-15T07:11:48","modified_gmt":"2019-04-15T07:11:48","slug":"evidence-of-clinical-pathology-abnormalities-in-people-with-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/evidence-of-clinical-pathology-abnormalities-in-people-with-me-cfs\/","title":{"rendered":"Evidence of clinical pathology abnormalities in people with ME\/CFS…"},"content":{"rendered":"

Evidence of clinical pathology abnormalities in people with Myalgic Encephalomyelitis\/ Chronic Fatigue Syndrome (ME\/CFS) from an analytic cross-sectional study<\/a>, by Luis Nacul, Barbara de Barros, Caroline C Kingdon, Jacqueline M Cliff, Taane G Clark, Kathleen Mudie, Hazel M Dockrell, Eliana M Lacerda in<\/span> Diagnostics <\/em>Vol 9, #2, p 41 [April 10, 2019]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/p>\n

Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a debilitating disease presenting with extreme fatigue, post-exertional malaise, and other symptoms. In the absence of a diagnostic biomarker, ME\/CFS is diagnosed clinically, although laboratory tests are routinely used to exclude alternative diagnoses.<\/p>\n

In this analytical cross-sectional study,<\/a> we aimed to explore potential haematological and biochemical markers for ME\/CFS, and disease severity. We reviewed laboratory test results from 272 people with ME\/CFS and 136 healthy controls participating in the UK ME\/CFS Biobank (UKMEB).<\/p>\n

\"\"<\/a>After corrections for multiple comparisons, most results were within the normal range, but people with severe ME\/CFS presented with lower median values (p < 0.001) of serum creatine kinase (CK; median=54 U\/L), compared to healthy controls (HCs; median=101.5 U\/L) and non-severe ME\/CFS (median=84 U\/L). The differences in CK concentrations persisted after adjusting for sex, age, body mass index, muscle mass, disease duration, and activity levels (odds ratio (OR) for being a severe case=0.05 (95% confidence interval (CI)=0.02-0.15) compared to controls, and OR=0.16 (95% CI=0.07-0.40), compared to mild cases).<\/p>\n

This is the first report that serum CK<\/a> concentrations are markedly reduced in severe ME\/CFS, and these results suggest that serum CK merits further investigation as a biomarker for severe ME\/CFS.<\/p>\n

Download full article<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Evidence of clinical pathology abnormalities in people with Myalgic Encephalomyelitis\/ Chronic Fatigue Syndrome (ME\/CFS) from an analytic cross-sectional study, by Luis Nacul, Barbara de Barros, Caroline C Kingdon, Jacqueline M Cliff, Taane G Clark, Kathleen Mudie, Hazel M Dockrell, Eliana … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4972,4170,3589,4971,614,3425,3529,41,4973,4813,4718,4970,36,4716,2667],"class_list":["post-20529","post","type-post","status-publish","format-standard","hentry","category-news","tag-barbara-de-barros","tag-biomarker","tag-caroline-c-kingdon","tag-creatine-kinase","tag-diagnostic-marker","tag-dr-luis-nacul","tag-eliana-m-lacerda","tag-energy-metabolism","tag-hazel-m-dockrell","tag-jacqueline-m-cliff","tag-kathleen-mudie","tag-serum-ck","tag-severe-me","tag-taane-g-clark","tag-uk-mecfs-biobank"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-5l7","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/20529","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=20529"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/20529\/revisions"}],"predecessor-version":[{"id":20540,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/20529\/revisions\/20540"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=20529"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=20529"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=20529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}