{"id":21120,"date":"2019-06-04T04:18:02","date_gmt":"2019-06-04T04:18:02","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=21120"},"modified":"2019-06-04T04:18:02","modified_gmt":"2019-06-04T04:18:02","slug":"a-possible-role-for-mitochondrial-derived-peptides-humanin-mots-c-in-patients-with-q-fever-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/a-possible-role-for-mitochondrial-derived-peptides-humanin-mots-c-in-patients-with-q-fever-cfs\/","title":{"rendered":"A possible role for mitochondrial-derived peptides humanin & MOTS-c in patients with Q fever & CFS"},"content":{"rendered":"

A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome<\/a>, by Ruud PH Raijmakers,\u00a0Anne F M Jansen, Stephan P Keijmel, Rob ter Horst, Megan E Roerink, Boris Novakovic, Leo AB\u00a0Joosten, Jos W M van der Meer, Mihai G Netea and Chantal P Bleeker-Roversen, in<\/span> Journal of Translational Medicine<\/em> 2019 17:157 [https:\/\/doi.org\/10.1186\/s12967-019-1906-3]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Background:<\/strong><\/p>\n

Q fever fatigue syndrome<\/a> (QFS) is a well-documented state of prolonged fatigue following around 20% of acute Q fever infections.<\/p>\n

\"\"<\/a>

General schema showing the relationships of the genome, transcriptome, proteome, and metabolome (lipidome).<\/p><\/div>\n

It has been hypothesized that low grade inflammation plays a role in its aetiology. In this study, we aimed to identify transcriptome<\/a> profiles that could aid to better understand the pathophysiology of QFS.<\/p>\n

Methods:<\/strong><\/p>\n

RNA<\/a> of monocytes<\/a> was collected from QFS patients (n\u2009=\u200910), chronic fatigue syndrome patients (CFS, n\u2009=\u200910), Q fever seropositive controls (n\u2009=\u200910), and healthy controls (n\u2009=\u200910) who were age- (\u00b1\u20095 years) and sex-matched. Transcriptome analysis was performed using RNA sequencing.<\/p>\n

Results:<\/strong><\/p>\n

Mitochondrial-derived peptide (MDP)-coding genes MT-RNR2 (humanin) and MT-RNR1 (MOTS-c) were differentially expressed when comparing QFS (\u2212 4.8 log2-fold-change P\u2009=\u20092.19\u2009\u00d7\u200910\u22129 and \u2212 4.9 log2-fold-change P\u2009=\u20094.69\u2009\u00d7\u200910\u22128), CFS (\u2212 5.2 log2-fold-change, P\u2009=3.49\u2009\u00d7\u200910\u221211 \u2212 4.4 log2-fold-change, P\u2009=\u20092.71\u2009\u00d7\u200910\u22129), and Q fever seropositive control (\u2212 3.7 log2-fold-change P\u2009=\u20091.78\u2009\u00d7\u200910\u22126 and \u2212 3.2 log2-fold-change P\u2009=\u20091.12 \u00d7 10\u22125) groups with healthy controls, resulting in a decreased median production of humanin in QFS patients (371 pg\/mL; Interquartile range, IQR, 325\u2013384), CFS patients (364 pg\/mL; IQR 316\u2013387), and asymptomatic Q fever seropositive controls (354 pg\/mL; 292\u2013393).<\/p>\n

Conclusions:<\/strong><\/p>\n

Expression of MDP-coding genes MT-RNR1 (MOTS-c<\/a>) and MT-RNR2 (humanin<\/a>) is decreased in CFS, QFS, and, to a lesser extent, in Q fever seropositive controls, resulting in a decreased production of humanin. These novel peptides might indeed be important in the pathophysiology of both QFS and CFS.<\/p>\n","protected":false},"excerpt":{"rendered":"

A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome, by Ruud PH Raijmakers,\u00a0Anne F M Jansen, Stephan P Keijmel, Rob ter Horst, Megan E Roerink, Boris Novakovic, Leo AB\u00a0Joosten, … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[5062,5064,5067,1939,5065,5108,3299,5066,5107,5110,5109,1999,2406,5060,5061,5063,4847],"class_list":["post-21120","post","type-post","status-publish","format-standard","hentry","category-news","tag-anne-f-m-jansen","tag-boris-novakovic","tag-chantal-p-bleeker-roversen","tag-jwm-van-der-meer","tag-leo-ab-joosten","tag-mdp-coding-genes","tag-megan-e-roerink","tag-mihai-g-netea","tag-mitochondrial-derived-peptide-coding-genes","tag-mt-rnr1-mots-c","tag-mt-rnr2-humanin","tag-q-fever-fatigue-syndrome","tag-qfs","tag-rob-ter-horst","tag-ruud-ph-raijmakers","tag-stephan-p-keijmel","tag-transcriptome"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-5uE","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21120","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=21120"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21120\/revisions"}],"predecessor-version":[{"id":21346,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21120\/revisions\/21346"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=21120"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=21120"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=21120"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}