{"id":21419,"date":"2019-12-15T21:26:51","date_gmt":"2019-12-15T21:26:51","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=21419"},"modified":"2020-10-15T21:32:22","modified_gmt":"2020-10-15T20:32:22","slug":"investigating-the-role-of-tgf-b-fatigue-in-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/investigating-the-role-of-tgf-b-fatigue-in-cfs\/","title":{"rendered":"Investigating the role of tgf-b & fatigue in CFS"},"content":{"rendered":"

Investigating the role of tgf-b and fatigue in chronic fatigue syndrome<\/a>, by Beth Dibnah, Emmanuella Traianos, Jessica Tarn, Dennis Lendrem, Wan Fai Ng in<\/span> Annals of the Rheumatic Diseases<\/em> Volume 78, Issue Suppl 2:1495 2019 [http:\/\/dx.doi.org\/10.1136\/annrheumdis-2019-eular.4690]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Background:<\/strong><\/p>\n

Chronic fatigue syndrome (CFS) is estimated to affect up to 5% of people in Europe and is more common in women than men. It is characterised by unexplained fatigue, post-exertional malaise and a range of other symptoms. Recent studies indicate potential immune dysfunction in CFS, specifically regarding cytokines and the adaptive behavioural response.<\/p>\n

Objectives:<\/strong><\/p>\n

\"\"<\/a>This study aims to investigate serum transforming growth factor-beta (TGF-\u03b2)<\/a> and the expression of the TGF-\u03b2 Receptor 1 (TGFBR1) and TGF-\u03b2 Receptor 2 (TGFBR2) genes, in relation to the fatigue associated with CFS.<\/p>\n

Methods: <\/strong><\/p>\n

Serum active and total TGF-\u03b2 concentrations were measured in 117 CFS patients and 40 HCs using a TGF-\u03b2 responsive luciferase bioassay. Expression levels of TGFBR1 and TGFBR2 were analysed using quantitative PCR. Fatigue was measured using the fatigue impact scale (FIS)1. FIS was categorised into three groups; \u2018mild\u2019 (0-80), \u2018moderate\u2019 (81-120) and \u2018severe\u2019 (121-160). Linear and ordinal regressions were performed on the continuous FIS and FIS categories respectively.<\/p>\n

Results:<\/strong><\/p>\n

Serum TGF-\u03b2 concentrations in the CFS group did not differ significantly compared with the HC group (p=0.58). TGF-\u03b2 concentrations showed no correlation with disease duration but there was a trend towards decreased TGF-\u03b2 with increasing symptom duration. There were no significant differences between the levels of TGFBR1 and TGFBR2 in any of the fatigue groups, or between HCs. Active TGF-\u03b2 concentrations were significantly elevated in the \u2018severe\u2019 FIS group compared to the \u2018mild\u2019 FIS group (p=0.04). Active\/total TGF-\u03b2 levels were significantly higher in the \u2018severe\u2019 FIS group than the \u2018mild\u2019 and \u2018moderate\u2019 FIS groups (p=0.02, p=0.03 respectively).<\/p>\n

Conclusion: <\/strong><\/p>\n

These data suggest no differences in serum concentrations of TGF-\u03b2 or expression of TGFBR1 and TGFBR2, between the HC and CFS groups. It also suggests no differences in expression levels of TGFBR1\/2 between any of the CFS fatigue groups. However, active\/total TGF-\u03b2 levels were increased in more severely fatigued patients based on FIS. This finding could be due to higher levels of circulating TGF-\u03b2, or increased amounts of TGF-\u03b2 activation. Further work is necessary to confirm this finding in a larger cohort of CFS patients, and to explore how this increase in TGF-\u03b2 relates to fatigue.<\/p>\n","protected":false},"excerpt":{"rendered":"

Investigating the role of tgf-b and fatigue in chronic fatigue syndrome, by Beth Dibnah, Emmanuella Traianos, Jessica Tarn, Dennis Lendrem, Wan Fai Ng in Annals of the Rheumatic Diseases Volume 78, Issue Suppl 2:1495 2019 [http:\/\/dx.doi.org\/10.1136\/annrheumdis-2019-eular.4690]   Research abstract: Background: … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4364,5159,5161,5160,1901,1902,2409],"class_list":["post-21419","post","type-post","status-publish","format-standard","hentry","category-news","tag-beth-dibnah","tag-dennis-lendrem","tag-emmanuella-traianos","tag-jessica-tarn","tag-tgf-","tag-transforming-growth-factor-beta","tag-wan-fai-ng"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-5zt","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21419","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=21419"}],"version-history":[{"count":7,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21419\/revisions"}],"predecessor-version":[{"id":28350,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21419\/revisions\/28350"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=21419"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=21419"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=21419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}