{"id":21421,"date":"2019-06-17T06:50:51","date_gmt":"2019-06-17T06:50:51","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=21421"},"modified":"2019-06-17T06:55:09","modified_gmt":"2019-06-17T06:55:09","slug":"orthostatic-intolerance-in-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/orthostatic-intolerance-in-cfs\/","title":{"rendered":"Orthostatic intolerance in CFS"},"content":{"rendered":"

Orthostatic intolerance in chronic fatigue syndrome, by Richard Garner and James N Baraniuk in Journal of Translational Medicine<\/a> 2019 17:185 [Published: 3 June 2019]
\nhttps:\/\/doi.org\/10.1186\/s12967-019-1935-y<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Background:<\/strong>
\nOrthostatic intolerance<\/a> (OI) is a significant problem for those with chronic fatigue syndrome (CFS). We aimed to characterize orthostatic intolerance in CFS and to study the effects of exercise on OI.<\/p>\n

Methods:<\/strong>
\nCFS (n\u2009=\u200939) and control (n\u2009=\u200925) subjects had recumbent and standing symptoms assessed using the 20-point, anchored, ordinal Gracely Box Scale before and after submaximal exercise. The change in heart rate (\u0394HR\u2009\u2265\u200930\u00a0bpm) identified Postural Orthostatic Tachycardia Syndrome (POTS) before and after exercise, and the transient, exercise-induced postural tachycardia Stress Test Activated Reversible Tachycardia (START) phenotype only after exercise.<\/p>\n

Results:<\/strong>
\nDizziness and lightheadedness were found in 41% of recumbent CFS subjects and in 72% of standing CFS subjects. Orthostatic tachycardia did not account for OI symptoms in CFS. ROC analysis with a threshold\u2009\u2265\u20092\/20 on the Gracely Box Scale stratified CFS subjects into three groups: No OI (symptoms\u2009<\u20092), Postural OI (only standing symptoms\u2009\u2265\u20092), and Persistent OI (recumbent and standing symptoms\u2009\u2265\u20092).<\/p>\n

\"\"<\/a><\/p>\n

Conclusions:<\/strong>
\nDizziness and Lightheadedness symptoms while recumbent are an underreported finding in CFS and should be measured when doing a clinical evaluation to diagnose orthostatic intolerance. POTS was found in 6 and START was found in 10 CFS subjects. Persistent OI had symptoms while recumbent and standing, highest symptom severity, and lability in symptoms after exercise.<\/p>\n

Trial registration<\/strong>: \u00a0https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03567811<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Orthostatic intolerance in chronic fatigue syndrome, by Richard Garner and James N Baraniuk in Journal of Translational Medicine 2019 17:185 [Published: 3 June 2019] https:\/\/doi.org\/10.1186\/s12967-019-1935-y   Research abstract: Background: Orthostatic intolerance (OI) is a significant problem for those with chronic … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[5134,3894,5135,493,492,332,331,5136,5138,5137],"class_list":["post-21421","post","type-post","status-publish","format-standard","hentry","category-news","tag-dizziness","tag-dr-james-n-baraniuk","tag-light-headedness","tag-oi","tag-orthostatic-intolerance","tag-postural-orthostatic-tachycardia-syndrome","tag-pots","tag-richard-garner","tag-start","tag-stress-test-activated-reversible-tachycardia"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-5zv","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21421","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=21421"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21421\/revisions"}],"predecessor-version":[{"id":21492,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21421\/revisions\/21492"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=21421"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=21421"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=21421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}