{"id":21423,"date":"2019-06-13T06:20:51","date_gmt":"2019-06-13T06:20:51","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=21423"},"modified":"2019-06-13T06:20:51","modified_gmt":"2019-06-13T06:20:51","slug":"abnormal-blood-lactate-accumulation-during-repeated-exercise-testing-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/abnormal-blood-lactate-accumulation-during-repeated-exercise-testing-in-me-cfs\/","title":{"rendered":"Abnormal blood lactate accumulation during repeated exercise testing in ME\/CFS"},"content":{"rendered":"

Abnormal blood lactate accumulation during repeated exercise testing in myalgic encephalomyelitis\/chronic fatigue syndrome<\/a>, by Katarina Lien, Bj\u00f8rn Johansen, Marit B Veier\u00f8d, Annicke S Haslestad, Siv K B\u00f8hn, Morten N Melsom, Kristin R Kardel, Per O Iversen in<\/span> Physiological reports <\/em>vol 7, issue 11, June 2019 [Published: 03 June 2019] https:\/\/doi.org\/10.14814\/phy2.14138<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

\"\"<\/a>Post\u2010exertional malaise and delayed recovery are hallmark symptoms of myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS). Studies on repeated cardiopulmonary exercise testing (CPET) show that previous exercise negatively affects oxygen uptake (VO2) and power output (PO) in ME\/CFS. Whether this affects arterial lactate concentrations<\/a> ([Laa]) is unknown.<\/p>\n

We studied 18 female patients (18\u201350\u00a0years) fulfilling the Canadian Consensus Criteria for ME\/CFS and 15 healthy females (18\u201350\u00a0years) who underwent repeated CPETs 24\u00a0h apart (CPET1\u00a0and CPET2) with [Laa] measured every 30th second.<\/p>\n

VO2 at peak exercise (VO2peak) was lower in patients than in controls on CPET1 (P < 0.001) and decreased in patients on CPET2 (P < 0.001). However, the difference in VO2peak between CPETs did not differ significantly between groups. [Laa] per PO was higher in patients during both CPETs (Pinteraction < 0.001), but increased in patients and decreased in controls from CPET1 to CPET2 (Pinteraction < 0.001).<\/p>\n

Patients had lower VO2 (P = 0.02) and PO (P = 0.002) at the gas exchange threshold (GET, the point where CO2 production increases relative to VO2), but relative intensity (%VO2peak) and [Laa] at GET did not differ significantly from controls on CPET1. Patients had a reduction in VO2 (P = 0.02) and PO (P = 0.01) at GET on CPET2, but no significant differences in %VO2peak and [Laa] at GET between CPETs.<\/p>\n

Controls had no significant differences in VO2, PO or %VO2peak at GET between CPETs, but [Laa] at GET was reduced on CPET2(P = 0.008).<\/p>\n

In conclusion, previous exercise deteriorates physical performance and increases [Laa] during exercise in patients with ME\/CFS while it lowers [Laa] in healthy subjects.<\/p>\n

Funding Information: The Norwegian Extra Foundation and The Norwegian ME\u2010Association.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Abnormal blood lactate accumulation during repeated exercise testing in myalgic encephalomyelitis\/chronic fatigue syndrome, by Katarina Lien, Bj\u00f8rn Johansen, Marit B Veier\u00f8d, Annicke S Haslestad, Siv K B\u00f8hn, Morten N Melsom, Kristin R Kardel, Per O Iversen in Physiological reports vol … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3049,5122,5124,5125,516,5117,5119,5123,5120,584,5118,585,5121,714],"class_list":["post-21423","post","type-post","status-publish","format-standard","hentry","category-news","tag-2-day-cpet","tag-annicke-s-haslestad","tag-bjorn-johansen","tag-blood-lactate-accumulation","tag-cardiopulmonary-exercise-testing","tag-katarina-lien","tag-kristin-r-kardel","tag-marit-b-veierod","tag-morten-n-melsom","tag-pem","tag-per-o-iversen","tag-post-exertional-malaise","tag-siv-k-bohn","tag-vo2"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-5zx","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21423","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=21423"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21423\/revisions"}],"predecessor-version":[{"id":21461,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21423\/revisions\/21461"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=21423"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=21423"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=21423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}