{"id":21719,"date":"2019-07-12T06:44:22","date_gmt":"2019-07-12T06:44:22","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=21719"},"modified":"2019-07-12T06:44:22","modified_gmt":"2019-07-12T06:44:22","slug":"post-exertional-malaise-is-associated-with-hypermetabolism-hypoacetylation-purine-metabolism-deregulation-in-me-cfs-cases","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/post-exertional-malaise-is-associated-with-hypermetabolism-hypoacetylation-purine-metabolism-deregulation-in-me-cfs-cases\/","title":{"rendered":"Post-Exertional Malaise Is associated with hypermetabolism, hypoacetylation & purine metabolism deregulation in ME\/CFS cases"},"content":{"rendered":"

Post-Exertional Malaise is associated with hypermetabolism, hypoacetylation and purine metabolism deregulation in ME\/CFS cases<\/a>, by Neil R McGregor, Christopher W Armstrong, Donald P Lewis and Paul R Gooley in<\/span> Diagnostics\u00a0<\/em>2019, 9(3), 70; [Published: 4 July 2019] https:\/\/doi.org\/10.3390\/diagnostics9030070<\/h3>\n

\n

Research abstract:<\/strong><\/h3>\n

Post-exertional malaise (PEM) is a cardinal predictive symptom in the definition of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS). If the cases overexert themselves they have what is termed \u201cpayback\u201d resulting in a worsening of symptoms or relapse which can last for days, weeks or even months.<\/p>\n

The aim was to assess the changes in biochemistry associated with the cases self-reported PEM scores over a 7-day period and the frequency of reporting over a 12-month period.<\/p>\n

\"\"<\/a>Forty-seven ME\/CFS cases and age\/sex-matched controls had a clinical examination, completed questionnaires; were subjected to standard serum biochemistry; had their serum and urine metabolomes<\/a> analyzed in an observational study.<\/p>\n

Thirty-five of the 46 ME\/CFS cases reported PEM in the last 7-days and these were allocated to the PEM group. The principal biochemical change related to the 7-day severity of PEM was the fall in the purine<\/a> metabolite, hypoxanthine. This decrease correlated with alterations in the glucose:lactate ratio highly suggestive of a glycolytic anomaly. Increased excretion of urine metabolites within the 7-day response period indicated a hypermetabolic<\/a> event was occurring.<\/p>\n

Increases in urine excretion of methylhistidine (muscle protein degradation), mannitol (intestinal barrier deregulation) and acetate were noted with the hypermetabolic event. These data indicate hypoacetylation<\/a> was occurring, which may also be related to deregulation of multiple cytoplasmic enzymes and DNA histone regulation.<\/p>\n

These findings suggest the primary events associated with PEM were due to hypoacetylation and metabolite loss during the acute PEM response.<\/p>\n","protected":false},"excerpt":{"rendered":"

Post-Exertional Malaise is associated with hypermetabolism, hypoacetylation and purine metabolism deregulation in ME\/CFS cases, by Neil R McGregor, Christopher W Armstrong, Donald P Lewis and Paul R Gooley in Diagnostics\u00a02019, 9(3), 70; [Published: 4 July 2019] https:\/\/doi.org\/10.3390\/diagnostics9030070 Research abstract: Post-exertional … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4730,3806,3084,651,5196,5194,5193,1327,5195,5191,584,585,5192],"class_list":["post-21719","post","type-post","status-publish","format-standard","hentry","category-news","tag-christopher-w-armstrong","tag-donald-p-lewis","tag-dr-neil-mcgregor","tag-exercise","tag-histone-deacetylation","tag-hypermetabolism","tag-hypoacetylation","tag-metabolites","tag-methylhistidine","tag-paul-r-gooley","tag-pem","tag-post-exertional-malaise","tag-purine-metabolism-deregulation"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-5Ej","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21719","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=21719"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21719\/revisions"}],"predecessor-version":[{"id":21762,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21719\/revisions\/21762"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=21719"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=21719"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=21719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}