{"id":21974,"date":"2019-08-06T07:09:34","date_gmt":"2019-08-06T07:09:34","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=21974"},"modified":"2019-08-06T07:09:34","modified_gmt":"2019-08-06T07:09:34","slug":"metabolic-features-of-gulf-war-illness-similarities-differences-to-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/metabolic-features-of-gulf-war-illness-similarities-differences-to-cfs\/","title":{"rendered":"Metabolic features of Gulf War illness [similarities & differences to CFS]"},"content":{"rendered":"

Metabolic features of Gulf War illness<\/a>, by Robert K Naviaux, Jane C Naviaux, Kefeng Li, Lin Wang, Jonathan M Monk, A Taylor Bright, Hayley J Koslik, Janis B Ritchie, Beatrice A Golomb\u00a0in<\/span> PLoS ONE<\/em> 14(7): e0219531 [Published: July 26, 2019] https:\/\/doi.org\/10.1371\/journal.pone.0219531<\/h3>\n

Research abstract:<\/strong><\/h3>\n

Background<\/strong>
\nMore than 230,000 veterans\u2014about 1\/3 of US personnel deployed in the 1990\u20131991 Persian Gulf War\u2014developed chronic, multi-symptom health problems now called \u201cGulf War illness<\/a>\u201d (GWI), for which mechanisms and objective diagnostic signatures continue to be sought.<\/p>\n

Methods<\/strong>
\nTargeted, broad-spectrum serum metabolomics was used to gain insights into the biology of GWI. 40 male participants, included 20 veterans who met both Kansas and CDC diagnostic criteria for GWI and 20 nonveteran controls without similar symptoms that were 1:1 matched to GWI cases by age, sex, and ethnicity. Serum samples were collected and archived at -80\u00b0 C prior to testing. 358 metabolites from 46 biochemical pathways were measured by hydrophilic interaction liquid chromatography and tandem mass spectrometry.<\/p>\n

\"\"<\/a>

Metabolic similarities & differences between Gulf War illness & CFS<\/p><\/div>\n

Results<\/strong>
\nVeterans with GWI, compared to healthy controls, had abnormalities in 8 of 46 biochemical pathways<\/a> interrogated. Lipid abnormalities accounted for 78% of the metabolic impact. Fifteen ceramides and sphingomyelins, and four phosphatidylcholine lipids were increased.<\/p>\n

Five of the 8 pathways were shared with the previously reported metabolic phenotype of males with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS). However, 4 of the 5 shared pathways were regulated in opposite directions; key pathways that were up-regulated in GWI were down-regulated in ME\/CFS. The single pathway regulated in the same direction was purines, which were decreased.<\/p>\n

Conclusions<\/strong>
\nOur data show that despite heterogeneous exposure histories, a metabolic phenotype of GWI was clearly distinguished from controls. Metabolomic differences between GWI and ME\/CFS show that common clinical symptoms like fatigue can have different chemical mechanisms and different diagnostic implications. Larger studies will be needed to validate these findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

Metabolic features of Gulf War illness, by Robert K Naviaux, Jane C Naviaux, Kefeng Li, Lin Wang, Jonathan M Monk, A Taylor Bright, Hayley J Koslik, Janis B Ritchie, Beatrice A Golomb\u00a0in PLoS ONE 14(7): e0219531 [Published: July 26, 2019] … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[5228,5220,5229,2559,845,5222,5224,5221,5227,5225,5226,5230,5231,5223],"class_list":["post-21974","post","type-post","status-publish","format-standard","hentry","category-news","tag-a-taylor-bright","tag-beatrice-a-golomb","tag-biochemical-pathways","tag-dr-robert-naviaux","tag-gulf-war-illness","tag-hayley-j-koslik","tag-jane-c-naviaux","tag-janis-b-ritchie","tag-jonathan-m-monk","tag-kefeng-li","tag-lin-wang","tag-metabolic-pathways","tag-metabolic-phentoype","tag-robert-k-naviaux"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-5Iq","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21974","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=21974"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21974\/revisions"}],"predecessor-version":[{"id":22034,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/21974\/revisions\/22034"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=21974"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=21974"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=21974"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}