{"id":22196,"date":"2019-10-26T20:41:36","date_gmt":"2019-10-26T20:41:36","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=22196"},"modified":"2020-02-10T20:50:17","modified_gmt":"2020-02-10T20:50:17","slug":"shared-microglial-mechanisms-underpinning-depression-cfs-their-comorbidities","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/shared-microglial-mechanisms-underpinning-depression-cfs-their-comorbidities\/","title":{"rendered":"Shared microglial mechanisms underpinning depression & CFS & their comorbidities"},"content":{"rendered":"

Shared microglial mechanisms underpinning depression and chronic fatigue syndrome and their comorbidities<\/a>, by Adriano Jos\u00e9 Maia Chaves-Filho, Danielle S Macedo, David Freitas de Lucena, Michael Maes in<\/span> Behavioural Brain Research <\/em>Vol 372, 17 October 2019, 111975 [https:\/\/doi.org\/10.1016\/j.bbr.2019.111975]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

In 2011, it was reviewed that<\/p>\n

a) there is a strong co-occurrence between major depression and chronic fatigue syndrome (CFS), with fatigue and physio-somatic symptoms being key symptoms of depression, and depressive symptoms appearing during the course of CFS; and<\/p>\n

b) the comorbidity between both disorders may in part be explained by activated immune-inflammatory pathways, including increased translocation of Gram-negative bacteria and increased levels of pro-inflammatory cytokines, such as interleukin (IL)-1.<\/p>\n

Nevertheless, the possible involvement of activated microglia in this comorbidity has remained unclear. This paper aims to review microglial disturbances in major depression, CFS and their comorbidity.<\/p>\n

A comprehensive literature search was conducted using the PubMed \/ MEDLINE database to identify studies, which are relevant to this current review. Depressed patients present neuroinflammatory alterations, probably related to microglial activation, while animal models show that a microglial response to immune challenges including lipopolysaccharides is accompanied by depressive-like behaviors.<\/p>\n

Recent evidence from preclinical studies indicates that activated microglia have a key role in the onset of fatigue. In chronic inflammatory conditions, such as infections and senescence, microglia orchestrate an inflammatory microenvironment thereby causing fatigue.<\/p>\n

In conclusion, based on our review we may posit that shared immune-inflammatory pathways and especially activated microglia underpin comorbid depression and CFS. As such, microglial activation and neuro-inflammation may be promising targets to treat the overlapping manifestations of both depression and CFS.<\/p>\n","protected":false},"excerpt":{"rendered":"

Shared microglial mechanisms underpinning depression and chronic fatigue syndrome and their comorbidities, by Adriano Jos\u00e9 Maia Chaves-Filho, Danielle S Macedo, David Freitas de Lucena, Michael Maes in Behavioural Brain Research Vol 372, 17 October 2019, 111975 [https:\/\/doi.org\/10.1016\/j.bbr.2019.111975]   Research abstract: … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[5603,113,5602,5601,321,313,1959,4720,306],"class_list":["post-22196","post","type-post","status-publish","format-standard","hentry","category-news","tag-adriano-jose-maia-chaves-filho","tag-cytokines","tag-danielle-s-macedo","tag-david-freitas-de-lucena","tag-depression","tag-michael-maes","tag-microglia","tag-neuro-immune-dysregulation","tag-oxidative-stress"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-5M0","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/22196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=22196"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/22196\/revisions"}],"predecessor-version":[{"id":24350,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/22196\/revisions\/24350"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=22196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=22196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=22196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}