{"id":22232,"date":"2019-09-11T06:16:07","date_gmt":"2019-09-11T06:16:07","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=22232"},"modified":"2019-09-11T06:46:00","modified_gmt":"2019-09-11T06:46:00","slug":"inflammatory-proteins-are-altered-in-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/inflammatory-proteins-are-altered-in-cfs\/","title":{"rendered":"Inflammatory proteins are altered in CFS"},"content":{"rendered":"<h3><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0149763419306128\" target=\"_blank\" rel=\"noopener noreferrer\">Inflammatory proteins are altered in chronic fatigue syndrome &#8211; a systematic review and meta-analysis<\/a>, by Rebecca Strawbridge, Maria-Laura Sartor, Fraser Scott, Anthony J Cleare <span style=\"text-decoration: underline;\">in<\/span> <em>Neuroscience &amp; Biobehavioral Reviews<\/em>, August 26, 2019 [https:\/\/doi.org\/10.1016\/j.neubiorev.2019.08.011]<\/h3>\n<p>&nbsp;<\/p>\n<h3><strong>Highlights:<\/strong><\/h3>\n<ul>\n<li>42 studies meta-analysed, testing 20 proteins between patients with CFS and controls<\/li>\n<li>Patients had higher levels of 5 cytokines than controls (TNF, IL-2, IL-4, TGFb, CRP)<\/li>\n<li>Group differences were not significant for 12 proteins<\/li>\n<li>Results are heterogeneous but provide some support for an inflammatory role in CFS<\/li>\n<\/ul>\n<h3><strong>Review abstract:<\/strong><\/h3>\n<p><a href=\"https:\/\/wames.org.uk\/cms-english\/patients-with-fm-cfs-show-increased-hscrp-comared-to-healthy-controls\/blood-in-test-tube\/\" rel=\"attachment wp-att-21585\"><img data-recalc-dims=\"1\" decoding=\"async\" class=\"alignright size-medium wp-image-21585 lazyload\" data-src=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/06\/blood-in-test-tube.jpg?resize=200%2C300&#038;ssl=1\" alt=\"\" width=\"200\" height=\"300\" data-srcset=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/06\/blood-in-test-tube.jpg?resize=200%2C300&amp;ssl=1 200w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/06\/blood-in-test-tube.jpg?resize=100%2C150&amp;ssl=1 100w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/06\/blood-in-test-tube.jpg?resize=768%2C1152&amp;ssl=1 768w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/06\/blood-in-test-tube.jpg?resize=682%2C1024&amp;ssl=1 682w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/06\/blood-in-test-tube.jpg?w=853&amp;ssl=1 853w\" data-sizes=\"(max-width: 200px) 100vw, 200px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 200px; --smush-placeholder-aspect-ratio: 200\/300;\" \/><\/a>Immune dysfunction has been posited as a key element in the aetiology of\u00a0chronic fatigue syndrome (CFS) since the illness was first conceived.\u00a0 However, systematic reviews have yet to quantitatively synthesise\u00a0inflammatory biomarkers across the literature.<\/p>\n<p>We undertook a systematic review and meta-analysis to quantify available data on circulating inflammatory proteins, examining studies recruiting patients with a CFS diagnosis and a non-affected control group.<\/p>\n<p>Results were meta-analysed from 42 studies. Patients with CFS had significantly elevated tumour necrosis factor (ES\u2009=\u20090.274, p\u2009&lt;\u20090.001), interleukin-2 (ES\u2009=\u20090.203, p\u2009=\u20090.006), interleukin-4 (ES\u2009=\u20090.373, p\u2009=\u20090.004), transforming growth factor-\u03b2 (ES\u2009=\u20090.967, p\u2009&lt;\u20090.001) and c-reactive protein (ES\u2009=\u20090.622, p\u2009=\u20090.019). 12 proteins did not differ between groups.<\/p>\n<p>These data provide some support for an inflammatory component in CFS, although inconsistency of results indicates that inflammation is unlikely to be a primary feature in all those suffering from this disorder. It is hoped that further work will elucidate whether there are subgroups of patients with clinically-relevant inflammatory dysfunction, and whether inflammatory cytokines may provide a prognostic biomarker or moderate treatment effects.<\/p>\n<p><a href=\"http:\/\/sci-hub.tw\/https:\/\/doi.org\/10.1016\/j.neubiorev.2019.08.011\" target=\"_blank\" rel=\"noopener noreferrer\">Read full paper<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Inflammatory proteins are altered in chronic fatigue syndrome &#8211; a systematic review and meta-analysis, by Rebecca Strawbridge, Maria-Laura Sartor, Fraser Scott, Anthony J Cleare in Neuroscience &amp; Biobehavioral Reviews, August 26, 2019 [https:\/\/doi.org\/10.1016\/j.neubiorev.2019.08.011] &nbsp; Highlights: 42 studies meta-analysed, testing 20 &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/inflammatory-proteins-are-altered-in-cfs\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[2084,5281,447,1579,5290,5282,5280],"class_list":["post-22232","post","type-post","status-publish","format-standard","hentry","category-news","tag-anthony-j-cleare","tag-fraser-scott","tag-inflammation","tag-inflammatory-cytokines","tag-inflammatory-proteins","tag-maria-laura-sartor","tag-rebecca-strawbridge"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-5MA","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/22232","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=22232"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/22232\/revisions"}],"predecessor-version":[{"id":22392,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/22232\/revisions\/22392"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=22232"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=22232"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=22232"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}