{"id":22458,"date":"2019-09-18T07:41:51","date_gmt":"2019-09-18T07:41:51","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=22458"},"modified":"2019-09-18T07:42:45","modified_gmt":"2019-09-18T07:42:45","slug":"me-cfs-from-pathophysiological-insights-to-novel-therapeutic-opportunities","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/me-cfs-from-pathophysiological-insights-to-novel-therapeutic-opportunities\/","title":{"rendered":"ME\/CFS: From pathophysiological insights to novel therapeutic opportunities"},"content":{"rendered":"

Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: from pathophysiological insights to novel therapeutic opportunities<\/a>, by Gerwyn Morris, Basant K Puri, Adam J Walker, Michael Maes, Andre F Carvalho, Ken Walder, Catherine Mazza, Michael Berk in<\/span> Pharmacological Research<\/em> [Available online 8 September 2019] https:\/\/doi.org\/10.1016\/j.phrs.2019.104450<\/h3>\n

 <\/p>\n

Review abstract:<\/strong><\/h3>\n

Myalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS) is a common and disabling condition with a paucity of effective and evidence-based therapies reflecting a major unmet need.<\/p>\n

Cognitive behavioural therapy and graded exercise are of modest benefit for only some ME\/CFS patients, and many sufferers report aggravation of symptoms of fatigue with exercise.<\/p>\n

\"\"<\/a>The presence of a multiplicity of pathophysiological abnormalities, in at least the subgroup of people with ME\/CFS diagnosed with the current international consensus \u201cFukuda\u201d criteria, points to numerous potential therapeutic targets. Such abnormalities include extensive data showing that at least a subgroup has a pro-inflammatory state, increased oxidative and nitrosative stress, disruption of gut mucosal barriers and mitochondrial dysfunction together with dysregulated bioenergetics.<\/p>\n

In this paper, these pathways are summarised, and data regarding promising therapeutic options that target these pathways are highlighted; they include coenzyme Q10, melatonin, curcumin, molecular hydrogen and N-acetylcysteine. These data are promising yet preliminary, suggesting hopeful avenues to address this major unmet burden of illness.<\/p>\n

Read full paper<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: from pathophysiological insights to novel therapeutic opportunities, by Gerwyn Morris, Basant K Puri, Adam J Walker, Michael Maes, Andre F Carvalho, Ken Walder, Catherine Mazza, Michael Berk in Pharmacological Research [Available online 8 September 2019] https:\/\/doi.org\/10.1016\/j.phrs.2019.104450 … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[5313,5312,5310,716,5316,3777,453,5311,5317,313,5315,5314,2759,3778],"class_list":["post-22458","post","type-post","status-publish","format-standard","hentry","category-news","tag-adam-j-walker","tag-andre-f-carvalho","tag-catherine-mazza","tag-coenzyme-q10","tag-curcumin","tag-dr-basant-k-puri","tag-gerwyn-morris","tag-ken-walder","tag-melatonin","tag-michael-maes","tag-molecular-hydrogen","tag-n-acetylcysteine","tag-pharmaceutical-therapy","tag-prof-michael-berk"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-5Qe","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/22458","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=22458"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/22458\/revisions"}],"predecessor-version":[{"id":22476,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/22458\/revisions\/22476"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=22458"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=22458"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=22458"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}