{"id":22835,"date":"2019-10-29T08:48:28","date_gmt":"2019-10-29T08:48:28","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=22835"},"modified":"2019-10-29T08:55:56","modified_gmt":"2019-10-29T08:55:56","slug":"intra-brainstem-connectivity-is-impaired-in-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/intra-brainstem-connectivity-is-impaired-in-cfs\/","title":{"rendered":"Intra brainstem connectivity is impaired in CFS"},"content":{"rendered":"<h3><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2213158219303924\" target=\"_blank\" rel=\"noopener noreferrer\">Intra brainstem connectivity is impaired in chronic fatigue syndrome<\/a>, by Leighton R Barnden, Zack Y Shan, Donald R Staines, Sonya Marshall-Gradisnik, Kevin Finegan, Timothy Ireland, Sandeep Bhuta, <span style=\"text-decoration: underline;\">in<\/span> <em>NeuroImage: Clinical<\/em> Vol 24, 2019, [https:\/\/doi.org\/10.1016\/j.nicl.2019.102045]<\/h3>\n<p>&nbsp;<\/p>\n<h3><strong>Research highlights:<\/strong><\/h3>\n<ul>\n<li>RAS connectivity was detected in HC and CFS groups both during rest and task.<\/li>\n<li>Strong connections were active for CFS from hippocampus to midbrain and medulla.<\/li>\n<li>RAS connectivity was diminished in CFS in the brainstem and to the hippocampus.<\/li>\n<li>RAS nuclei generate oscillatory signals which facilitate thalamocortical signal coherence.<\/li>\n<li>Impaired RAS affects cortical coherence necessary for attention, memory and problem solving.<\/li>\n<\/ul>\n<h3><strong>Research abstract:<\/strong><\/h3>\n<div id=\"attachment_22855\" style=\"width: 283px\" class=\"wp-caption alignright\"><a href=\"https:\/\/wames.org.uk\/cms-english\/intra-brainstem-connectivity-is-impaired-in-cfs\/brain-stem-highlighted\/\" rel=\"attachment wp-att-22855\"><img data-recalc-dims=\"1\" decoding=\"async\" aria-describedby=\"caption-attachment-22855\" class=\"wp-image-22855 size-medium lazyload\" data-src=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/10\/brain-stem-highlighted.jpg?resize=273%2C300&#038;ssl=1\" alt=\"\" width=\"273\" height=\"300\" data-srcset=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/10\/brain-stem-highlighted.jpg?resize=273%2C300&amp;ssl=1 273w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/10\/brain-stem-highlighted.jpg?resize=136%2C150&amp;ssl=1 136w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/10\/brain-stem-highlighted.jpg?w=299&amp;ssl=1 299w\" data-sizes=\"(max-width: 273px) 100vw, 273px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 273px; --smush-placeholder-aspect-ratio: 273\/300;\" \/><\/a><p id=\"caption-attachment-22855\" class=\"wp-caption-text\">Brain stem highlighted<\/p><\/div>\n<p>In myalgic encephalomyelitis or chronic fatigue syndrome (ME\/CFS), abnormal <a href=\"https:\/\/www.nhsdirect.wales.nhs.uk\/Encyclopaedia\/m\/article\/mriscan\/\" target=\"_blank\" rel=\"noopener noreferrer\">MRI<\/a> correlations with symptom severity and autonomic measures have suggested impaired nerve signal conduction within the <a href=\"https:\/\/www.thoughtco.com\/brainstem-anatomy-373212\" target=\"_blank\" rel=\"noopener noreferrer\">brainstem<\/a>.<\/p>\n<p>Here we analyse fMRI correlations to directly test connectivity within and from the brainstem. Resting and task functional MRI (fMRI) were acquired for 45 ME\/CFS (Fukuda criteria) and 27 healthy controls (HC).<\/p>\n<p>We selected limited brainstem <a href=\"https:\/\/en.wikipedia.org\/wiki\/Reticular_formation#Ascending_reticular_activating_system\" target=\"_blank\" rel=\"noopener noreferrer\">reticular activation system<\/a> (RAS) regions-of-interest (ROIs) based on previous structural <a href=\"https:\/\/www.nhsdirect.wales.nhs.uk\/Encyclopaedia\/m\/article\/mriscan\/\" target=\"_blank\" rel=\"noopener noreferrer\">MRI<\/a> findings in a different ME\/CFS cohort (bilateral rostral medulla and midbrain cuneiform nucleus), the dorsal Raphe nucleus, and two subcortical ROIs (hippocampus subiculum and thalamus intralaminar nucleus) reported to have rich brainstem connections.<\/p>\n<p>When HC and ME\/CFS were analysed separately, significant correlations were detected for both groups during both rest and task, with stronger correlations during task than rest. Strong hippocampal connections with midbrain and medulla nuclei were detected for ME\/CFS. When corresponding correlations from HC and ME\/CFS were compared, ME\/CFS connectivity deficits were detected within the brainstem between the medulla and cuneiform nucleus and between the brainstem and hippocampus and intralaminar thalamus, but only during task.<\/p>\n<p>In CFS\/ME, weaker connectivity between some RAS nuclei was associated with increased symptom severity. RAS neuron oscillatory signals facilitate coherence in thalamo-cortical oscillations.<\/p>\n<p>Brainstem RAS connectivity deficits can explain autonomic changes and diminish <a href=\"https:\/\/en.wikipedia.org\/wiki\/Neural_oscillation\" target=\"_blank\" rel=\"noopener noreferrer\">cortical oscillatory coherence<\/a> which can impair attention, memory, cognitive function, sleep quality and muscle tone, all symptoms of ME\/CFS.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Intra brainstem connectivity is impaired in chronic fatigue syndrome, by Leighton R Barnden, Zack Y Shan, Donald R Staines, Sonya Marshall-Gradisnik, Kevin Finegan, Timothy Ireland, Sandeep Bhuta, in NeuroImage: Clinical Vol 24, 2019, [https:\/\/doi.org\/10.1016\/j.nicl.2019.102045] &nbsp; Research highlights: RAS connectivity was &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/intra-brainstem-connectivity-is-impaired-in-cfs\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[2572,3495,1249,1026,4418,2676,4582,4420,3875],"class_list":["post-22835","post","type-post","status-publish","format-standard","hentry","category-news","tag-brainstem","tag-dr-leighton-barnden","tag-dr-sonya-marshall-gradisnik","tag-fmri","tag-kevin-finegan","tag-prof-donald-staines","tag-sandeep-bhuta","tag-timothy-ireland","tag-zack-y-shan"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-5Wj","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/22835","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=22835"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/22835\/revisions"}],"predecessor-version":[{"id":22858,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/22835\/revisions\/22858"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=22835"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=22835"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=22835"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}