{"id":22841,"date":"2019-11-04T10:59:01","date_gmt":"2019-11-04T10:59:01","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=22841"},"modified":"2019-11-04T10:59:01","modified_gmt":"2019-11-04T10:59:01","slug":"evidence-of-altered-cardiac-autonomic-regulation-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/evidence-of-altered-cardiac-autonomic-regulation-in-me-cfs\/","title":{"rendered":"Evidence of altered cardiac autonomic regulation in ME\/CFS"},"content":{"rendered":"

Evidence of altered cardiac autonomic regulation in myalgic encephalomyelitis\/chronic fatigue syndrome: a systematic review and meta-analysis<\/a>, by Maximillian J Nelson,\u00a0Jasvir S Bahl, Jonathan D Buckley, Rebecca L Thomson,\u00a0Kade Davison in Medicine<\/em> October 2019 , Vol 98, Issue 43 [doi: 10.1097\/MD.0000000000017600]<\/h3>\n

 <\/p>\n

Review abstract:<\/strong><\/p>\n

Background:<\/strong><\/p>\n

\"\"<\/a>Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) is a complex condition with no reliable diagnostic biomarkers. Studies have shown evidence of autonomic dysfunction in patients with ME\/CFS, but results have been equivocal. Heart rate (HR) parameters can reflect changes in autonomic function in healthy individuals; however, this has not been thoroughly evaluated in ME\/CFS.<\/p>\n

Methods:<\/strong><\/p>\n

A systematic database search for case-control literature was performed. Meta-analysis was performed to determine differences in HR parameters between ME\/CFS patients and controls.<\/p>\n

Results:\u00a0<\/strong><\/p>\n

Sixty-four articles were included in the systematic review. HR parameters assessed in ME\/CFS patients and controls were grouped into ten categories: resting HR (RHR), maximal HR (HRmax), HR during submaximal exercise, HR response to head-up tilt testing (HRtilt), resting HR variability (HRVrest), HR variability during head-up tilt testing (HRVtilt), orthostatic HR response (HROR), HR during mental task(s) (HRmentaltask), daily average HR (HRdailyaverage), and HR recovery (HRR) Meta-analysis revealed RHR (MD \u00b1 95% CI = 4.14 \u00b1 1.38,\u00a0P\u00a0< .001), HRtilt\u00a0(SMD \u00b1 95% CI = 0.92 \u00b1 0.24,\u00a0P\u00a0< .001), HROR\u00a0(0.50 \u00b1 0.27,\u00a0P\u00a0< .001), and the ratio of low frequency power to high frequency power of HRVrest\u00a0(0.39 \u00b1 0.22,\u00a0P\u00a0< .001) were higher in ME\/CFS patients compared to controls, while HRmax\u00a0(MD \u00b1 95% CI = \u201313.81 \u00b1 4.15,\u00a0P\u00a0< .001), HR at anaerobic threshold (SMD \u00b1 95% CI = \u20130.44 \u00b1 0.30,\u00a0P\u00a0= 0.005) and the high frequency portion of HRVrest\u00a0(\u20130.34 \u00b1 0.22,\u00a0P\u00a0= .002) were lower in ME\/CFS patients.<\/p>\n

Conclusions:\u00a0<\/strong><\/p>\n

The differences in HR parameters identified by the meta-analysis indicate that ME\/CFS patients have altered autonomic cardiac regulation when compared to healthy controls. These alterations in HR parameters may be symptomatic of the condition.<\/p>\n","protected":false},"excerpt":{"rendered":"

Evidence of altered cardiac autonomic regulation in myalgic encephalomyelitis\/chronic fatigue syndrome: a systematic review and meta-analysis, by Maximillian J Nelson,\u00a0Jasvir S Bahl, Jonathan D Buckley, Rebecca L Thomson,\u00a0Kade Davison in Medicine October 2019 , Vol 98, Issue 43 [doi: 10.1097\/MD.0000000000017600] … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[763,5353,5354,5355,4940,4937,4941,4939],"class_list":["post-22841","post","type-post","status-publish","format-standard","hentry","category-news","tag-autonomic-dysfunction","tag-cardiac-regulation","tag-heart-rate-regulation","tag-jasvir-s-bahl","tag-jonathan-d-buckley","tag-kade-davison","tag-maximillian-j-nelson","tag-rebecca-l-thomson"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-5Wp","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/22841","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=22841"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/22841\/revisions"}],"predecessor-version":[{"id":22938,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/22841\/revisions\/22938"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=22841"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=22841"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=22841"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}