{"id":23141,"date":"2020-01-08T21:30:46","date_gmt":"2020-01-08T21:30:46","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=23141"},"modified":"2020-01-08T21:30:46","modified_gmt":"2020-01-08T21:30:46","slug":"autonomic-markers-cfs-post-exertion-states","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/autonomic-markers-cfs-post-exertion-states\/","title":{"rendered":"Autonomic markers, CFS &#038; post-exertion states"},"content":{"rendered":"<h3><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022399919309055\" target=\"_blank\" rel=\"noopener noreferrer\">Autonomic markers, chronic fatigue syndrome, and post-exertion states<\/a>, by Fred Friedberg <span style=\"text-decoration: underline;\">in<\/span> <em>Journal of Psychosomatic Research<\/em> Vol 127, Dec 2019, [https:\/\/doi.org\/10.1016\/j.jpsychores.2019.109845]<\/h3>\n<p>&nbsp;<\/p>\n<h3><strong>Article extracts:<\/strong><\/h3>\n<p>A large body of evidence suggests that autonomic imbalance, i.e., <a href=\"https:\/\/franklincardiovascular.com\/overactive-sympathetic-nervous-system\/\" target=\"_blank\" rel=\"noopener noreferrer\">hyperactive sympathetic nervous system<\/a> and hypoactive parasympathetic nervous system, is associated with a number of pathological conditions and diseases, and may be a final common pathway to increased morbidity and mortality [1].<\/p>\n<p><a href=\"https:\/\/wames.org.uk\/cms-english\/chronotropic-intolerance-an-overlooked-determinant-of-symptoms-activity-limitation-in-me-cfs\/heart-rate\/\" rel=\"attachment wp-att-20235\"><img data-recalc-dims=\"1\" decoding=\"async\" class=\"alignright size-medium wp-image-20235 lazyload\" data-src=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/03\/heart-rate.jpg?resize=300%2C278&#038;ssl=1\" alt=\"\" width=\"300\" height=\"278\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/278;\" \/><\/a>Heart rate variability (HRV), a measure of inter-beat interval fluctuations and more broadly of <a href=\"https:\/\/en.wikipedia.org\/wiki\/Vagal_tone\" target=\"_blank\" rel=\"noopener noreferrer\">parasympathetic (vagal) activity<\/a> has been successfully used to index <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19910061\" target=\"_blank\" rel=\"noopener noreferrer\">autonomic imbalances.<\/a><\/p>\n<p>&#8230;In conclusion, reduced HRV may be a sensitive (and conveniently assessed) autonomic indicator of post-exertional worsening and a correlate of activity and fatigue that may differentiate CFS from healthy controls. If negative changes in HRV are uniquely associated with greater PEM and day-to-day illness fluctuations in CFS, then its potential as an illness marker can be productively tested in exertional challenge designs that amplify PEM-related symptom exacerbations.<\/p>\n<p><a href=\"http:\/\/sci-hub.tw\/https:\/\/doi.org\/10.1016\/j.jpsychores.2019.109845\" target=\"_blank\" rel=\"noopener noreferrer\">Read full paper<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Autonomic markers, chronic fatigue syndrome, and post-exertion states, by Fred Friedberg in Journal of Psychosomatic Research Vol 127, Dec 2019, [https:\/\/doi.org\/10.1016\/j.jpsychores.2019.109845] &nbsp; Article extracts: A large body of evidence suggests that autonomic imbalance, i.e., hyperactive sympathetic nervous system and hypoactive &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/autonomic-markers-cfs-post-exertion-states\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[5435,2347,291,292,584,585],"class_list":["post-23141","post","type-post","status-publish","format-standard","hentry","category-news","tag-autonomic-markers","tag-dr-fred-friedberg","tag-heart-rate-variability","tag-hrv","tag-pem","tag-post-exertional-malaise"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-61f","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/23141","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=23141"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/23141\/revisions"}],"predecessor-version":[{"id":23778,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/23141\/revisions\/23778"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=23141"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=23141"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=23141"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}