{"id":23609,"date":"2020-01-14T22:15:59","date_gmt":"2020-01-14T22:15:59","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=23609"},"modified":"2020-01-14T22:15:59","modified_gmt":"2020-01-14T22:15:59","slug":"a-neuro-inflammatory-model-can-explain-the-onset-symptoms-and-flare-ups-of-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/a-neuro-inflammatory-model-can-explain-the-onset-symptoms-and-flare-ups-of-me-cfs\/","title":{"rendered":"A neuro-inflammatory model can explain the onset, symptoms and flare-ups of ME\/CFS"},"content":{"rendered":"

A neuro-inflammatory model can explain the onset, symptoms and flare-ups of myalgic encephalomyelitis\/chronic fatigue syndrome<\/a>, by Angus Mackay in<\/span> Journal of Primary Health Care<\/em> 11(4) 300-307 2019 [https:\/\/doi.org\/10.1071\/HC19041]<\/h3>\n

 <\/p>\n

Abstract:<\/strong><\/h3>\n

A neuro-inflammatory model is proposed to explain the onset, symptoms and perpetuation of myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) via characteristic flare-ups (relapses).<\/p>\n

In this article, I explore the proposition that a range of triggers (intense physiological stressors such as severe viral infections, chemical toxin exposure or emotional trauma) in ME\/CFS-predisposed people causes disruption in the neural circuitry of the hypothalamus (paraventricular nucleus), which induces a neuro-inflammatory reaction in the brain and central nervous system of ME\/CFS patients, via over-active innate immune (glial) cells.<\/p>\n

\"\"<\/a><\/p>\n

Resulting dysfunction of the limbic system, the hypothalamus and consequently of the autonomic nervous system can then account for the diverse range of ME\/CFS symptoms. Ongoing stressors feed into a compromised (inflamed) hypothalamus and if a certain (but variable) threshold is exceeded, a flare-up will ensue, inducing further ongoing neuro-inflammation in the central nervous system, thus perpetuating the disease indefinitely.<\/p>\n","protected":false},"excerpt":{"rendered":"

A neuro-inflammatory model can explain the onset, symptoms and flare-ups of myalgic encephalomyelitis\/chronic fatigue syndrome, by Angus Mackay in Journal of Primary Health Care 11(4) 300-307 2019 [https:\/\/doi.org\/10.1071\/HC19041]   Abstract: A neuro-inflammatory model is proposed to explain the onset, symptoms … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4844,2937,2574,1557,2936],"class_list":["post-23609","post","type-post","status-publish","format-standard","hentry","category-news","tag-angus-mackay","tag-flare-up","tag-hypothalamus","tag-neuro-inflammatory","tag-relapse"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-68N","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/23609","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=23609"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/23609\/revisions"}],"predecessor-version":[{"id":23872,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/23609\/revisions\/23872"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=23609"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=23609"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=23609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}