{"id":23671,"date":"2020-01-13T10:07:56","date_gmt":"2020-01-13T10:07:56","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=23671"},"modified":"2020-01-13T10:07:56","modified_gmt":"2020-01-13T10:07:56","slug":"the-role-of-low-grade-inflammation-in-me-cfs-associations-with-symptoms","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/the-role-of-low-grade-inflammation-in-me-cfs-associations-with-symptoms\/","title":{"rendered":"The role of low-grade inflammation in ME\/CFS &#8211; associations with symptoms"},"content":{"rendered":"<h3><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0306453019313198\" target=\"_blank\" rel=\"noopener noreferrer\">The role of low-grade inflammation in ME\/CFS (Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome) &#8211; associations with symptoms<\/a>, by\u00a0Martin A Jonsj\u00f6, Gunnar L Olsson, Rikard K Wicksell, Kjell Alving, Linda Holmstr\u00f6m, Anna Andreasson <span style=\"text-decoration: underline;\">in<\/span> <em>Psychoneuroendocrinology<\/em> Vol 113, March 2020, 104578 [https:\/\/doi.org\/10.1016\/j.psyneuen.2019.104578]<\/h3>\n<p>&nbsp;<\/p>\n<h3><strong>Highlights<\/strong><\/h3>\n<ul>\n<li>Associations between inflammatory markers and common symptoms in ME\/CFS.<\/li>\n<li>Higher levels of markers were significantly associated with higher levels of symptoms.<\/li>\n<li>Biological sex moderated several associations.<\/li>\n<\/ul>\n<h3><strong>Abstract<\/strong><\/h3>\n<p><strong>Background:<\/strong><br \/>\n<a href=\"https:\/\/wames.org.uk\/cms-english\/patients-with-fm-cfs-show-increased-hscrp-comared-to-healthy-controls\/blood-in-test-tube\/\" rel=\"attachment wp-att-21585\"><img data-recalc-dims=\"1\" decoding=\"async\" class=\"alignright size-medium wp-image-21585 lazyload\" data-src=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/06\/blood-in-test-tube.jpg?resize=200%2C300&#038;ssl=1\" alt=\"\" width=\"200\" height=\"300\" data-srcset=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/06\/blood-in-test-tube.jpg?resize=200%2C300&amp;ssl=1 200w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/06\/blood-in-test-tube.jpg?resize=100%2C150&amp;ssl=1 100w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/06\/blood-in-test-tube.jpg?resize=768%2C1152&amp;ssl=1 768w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/06\/blood-in-test-tube.jpg?resize=682%2C1024&amp;ssl=1 682w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/06\/blood-in-test-tube.jpg?w=853&amp;ssl=1 853w\" data-sizes=\"(max-width: 200px) 100vw, 200px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 200px; --smush-placeholder-aspect-ratio: 200\/300;\" \/><\/a>Patients with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) often present with a range of flu-like symptoms resembling <a href=\"https:\/\/en.wikipedia.org\/wiki\/Sickness_behavior\" target=\"_blank\" rel=\"noopener noreferrer\">sickness behavior<\/a> as well as widespread pain and concentration deficits. The aim of this study was to explore the association between <a href=\"https:\/\/patient.info\/treatment-medication\/blood-tests\/blood-tests-to-detect-inflammation\" target=\"_blank\" rel=\"noopener noreferrer\">inflammatory markers<\/a> previously shown to be related to fatigue severity in ME\/CFS and common ME\/CFS symptoms post-exertional fatigue, impaired cognitive processing, musculoskeletal pain and recurrent flu-like symptoms, and the moderating effect of sex on these associations.<\/p>\n<p><strong>Methods:<\/strong><br \/>\n53 adult patients diagnosed with ME\/CFS at a specialist clinic were included in the study. <a href=\"https:\/\/www.webmd.com\/diabetes\/qa\/what-is-the-fasting-plasma-glucose-fpg-test\" target=\"_blank\" rel=\"noopener noreferrer\">Fasting blood plasma<\/a> was analyzed using the Olink Proseek Multiplex Inflammation panel (\u03b2-NGF, CCL11, CXCL1, CXCL10, IL-6, IL-7, IL-8, IL-10, IL-18, TGF-\u03b1, TGF-\u03b2-1 and SCF) and BioRad Human Cytokine Type 1 assay (TNF-\u03b1). Participants rated the average severity of symptoms (0\u201310) based on the 2011 International Consensus Criteria of ME\/CFS during a structured clinical interview. Associations between inflammatory markers and symptom severity were analyzed using <a href=\"https:\/\/methods.sagepub.com\/reference\/the-sage-encyclopedia-of-communication-research-methods\/i13380.xml\" target=\"_blank\" rel=\"noopener noreferrer\">bivariate correlations<\/a> and <a href=\"https:\/\/www.statisticssolutions.com\/directory-of-statistical-analyses-general-moderator-variable\/\" target=\"_blank\" rel=\"noopener noreferrer\">moderated regression analyses<\/a> bootstrapped with 5000 repetitions.<\/p>\n<p><strong>Results and conclusions:<\/strong><br \/>\nOnly <a href=\"https:\/\/www.uniprot.org\/uniprot\/P01138\" target=\"_blank\" rel=\"noopener noreferrer\">\u03b2-NGF<\/a> was associated with the fatigue severity measure. However, higher levels of CCL11, CXCL10, IL-7, TNF-\u03b1 and TGF-\u03b2-1 were significantly associated with higher levels of impaired cognitive processing and musculoskeletal pain, and sex was a significant moderator for CXCL10, IL-7 and TGF-\u03b2-1. Future studies should investigate the relationship between inflammatory markers and key symptoms in ME\/CFS in a longitudinal design in order to explore if and for whom low-grade inflammation may contribute to illness development.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The role of low-grade inflammation in ME\/CFS (Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome) &#8211; associations with symptoms, by\u00a0Martin A Jonsj\u00f6, Gunnar L Olsson, Rikard K Wicksell, Kjell Alving, Linda Holmstr\u00f6m, Anna Andreasson in Psychoneuroendocrinology Vol 113, March 2020, 104578 [https:\/\/doi.org\/10.1016\/j.psyneuen.2019.104578] &nbsp; Highlights &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/the-role-of-low-grade-inflammation-in-me-cfs-associations-with-symptoms\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[5486,5512,5482,5513,5484,5485,5514,5481,5483,5511],"class_list":["post-23671","post","type-post","status-publish","format-standard","hentry","category-news","tag-anna-andreasson","tag-beta-nerve-growth-factor","tag-gunnar-l-olsson","tag-inflammatory-markers","tag-kjell-alving","tag-linda-holmstrom","tag-low-grade-inflammation","tag-martin-a-jonsjo","tag-rikard-k-wicksell","tag--ngf"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-69N","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/23671","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=23671"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/23671\/revisions"}],"predecessor-version":[{"id":23821,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/23671\/revisions\/23821"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=23671"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=23671"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=23671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}