{"id":23834,"date":"2020-01-16T23:58:21","date_gmt":"2020-01-16T23:58:21","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=23834"},"modified":"2020-01-16T23:58:21","modified_gmt":"2020-01-16T23:58:21","slug":"reduced-heart-rate-variability-predicts-fatigue-severity-in-individuals-with-cfs-me","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/reduced-heart-rate-variability-predicts-fatigue-severity-in-individuals-with-cfs-me\/","title":{"rendered":"Reduced heart rate variability predicts fatigue severity in individuals with CFS\/ME"},"content":{"rendered":"

Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome\/myalgic encephalomyelitis<\/a>, by Rosa Mar\u00eda Escorihuela, Llu\u00eds Capdevila, Juan Ramos Castro, Mar\u00eda Cleof\u00e9 Zaragoz\u00e0, Sara Maurel, Jos\u00e9 Alegre & Jes\u00fas Castro-Marrero in<\/span> Journal of Translational Medicine<\/em>\u00a0volume\u00a018, Article\u00a0number:\u00a04\u00a0(2020)<\/h3>\n

 <\/p>\n

Abstract:<\/strong><\/h3>\n

Background:<\/strong>
\n\"\"<\/a>Heart rate variability<\/a> (HRV) is an objective, non-invasive tool to assessing autonomic dysfunction in chronic fatigue syndrome\/myalgic encephalomyelitis (CFS\/ME). People with CFS\/ME tend to have lower HRV; however, in the literature there are only a few previous studies (most of them inconclusive) on their association with illness-related complaints. To address this issue, we assessed the value of different diurnal HRV parameters as potential biomarker in CFS\/ME and also investigated the relationship between these HRV indices and self-reported symptoms in individuals with CFS\/ME.<\/p>\n

Methods:<\/strong>
\nIn this case\u2013control study, 45 female patients who met the 1994 CDC\/Fukuda definition for CFS\/ME and 25 age- and gender-matched healthy controls underwent HRV recording-resting state tests. The intervals between consecutive heartbeats (RR) were continuously recorded over three 5-min periods. Time- and frequency-domain analyses were applied to estimate HRV variables. Demographic and clinical features, and self-reported symptom measures were also recorded.<\/p>\n

Results:<\/strong>
\nCFS\/ME patients showed significantly higher scores in all symptom questionnaires (p\u2009<\u20090.001), decreased RR intervals (p\u2009<\u20090.01), and decreased HRV time- and frequency-domain parameters (p\u2009<\u20090.005), except for the LF\/HF ratio than in the healthy controls. Overall, the correlation analysis reached significant associations between the questionnaires scores and HRV time- and frequency-domain measurements (p\u2009<\u20090.05). Furthermore, separate linear regression analyses showed significant relationships between self-reported fatigue symptoms and mean RR (p\u2009=\u20090.005), RMSSD (p\u2009=\u20090.0268) and HFnu indices (p\u2009=\u20090.0067) in CFS\/ME patients, but not in healthy controls.<\/p>\n

Conclusions:<\/strong>
\nOur findings suggest that ANS dysfunction presenting as increased sympathetic hyperactivity<\/a> may contribute to fatigue severity in individuals with ME\/CFS. Further studies comparing short- and long-term HRV recording and self-reported outcome measures with previous studies in larger CFS\/ME cohorts are urgently warranted.<\/p>\n","protected":false},"excerpt":{"rendered":"

Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome\/myalgic encephalomyelitis, by Rosa Mar\u00eda Escorihuela, Llu\u00eds Capdevila, Juan Ramos Castro, Mar\u00eda Cleof\u00e9 Zaragoz\u00e0, Sara Maurel, Jos\u00e9 Alegre & Jes\u00fas Castro-Marrero in Journal of Translational Medicine\u00a0volume\u00a018, Article\u00a0number:\u00a04\u00a0(2020)   … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[9,291,292,4284,4289,5518,5519,4287,5520,5517],"class_list":["post-23834","post","type-post","status-publish","format-standard","hentry","category-news","tag-chronic-fatigue","tag-heart-rate-variability","tag-hrv","tag-jesus-castro-marrero","tag-jose-alegre","tag-juan-ramos-castro","tag-lluis-capdevila","tag-maria-cleofe-zaragoza","tag-rosa-maria-escorihuela","tag-sara-maurel"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-6cq","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/23834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=23834"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/23834\/revisions"}],"predecessor-version":[{"id":23911,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/23834\/revisions\/23911"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=23834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=23834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=23834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}