{"id":23840,"date":"2020-01-29T21:33:02","date_gmt":"2020-01-29T21:33:02","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=23840"},"modified":"2020-01-29T21:33:02","modified_gmt":"2020-01-29T21:33:02","slug":"systematic-review-of-randomized-controlled-trials-for-cfs-me","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/systematic-review-of-randomized-controlled-trials-for-cfs-me\/","title":{"rendered":"Systematic review of randomized controlled trials for CFS\/ME"},"content":{"rendered":"

Systematic review of randomized controlled trials for chronic fatigue syndrome\/ myalgic encephalomyelitis (CFS\/ME),<\/a> by Do-Young Kim, Jin-Seok Lee, Samuel-Young Park, Soo-Jin Kim & Chang-Gue Son in<\/span> Journal of Translational Medicine<\/em> vol 18, no. 7 (2020)<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Background:<\/strong>
\nAlthough medical requirements are urgent, no effective intervention has been proven for chronic fatigue syndrome\/myalgic encephalomyelitis (CFS\/ME). To facilitate the development of new therapeutics, we systematically reviewed the randomized controlled trials (RCTs) for CFS\/ME to date.<\/p>\n

Methods:<\/strong>
\nRCTs targeting CFS\/ME were surveyed using two electronic databases, PubMed and the Cochrane library, through April 2019. We included only RCTs that targeted fatigue-related symptoms, and we analyzed the data in terms of the characteristics of the participants, case definitions, primary measurements, and interventions with overall outcomes.<\/p>\n

Results:<\/strong>
\nAmong 513 potentially relevant articles, 55 RCTs met our inclusion criteria; these included 25 RCTs of 22 different pharmacological interventions, 28 RCTs of 18 non-pharmacological interventions and 2 RCTs of combined interventions. These studies accounted for a total of 6316 participants (1568 males and 4748 females, 5859 adults and 457 adolescents). CDC 1994 (Fukuda) criteria were mostly used for case definitions (42 RCTs, 76.4%), and the primary measurement tools included the Checklist Individual Strength (CIS, 36.4%) and the 36-item Short Form health survey (SF-36, 30.9%).<\/p>\n

\"\"<\/a><\/p>\n

Eight interventions showed statistical significance: 3 pharmacological (Staphypan Berna, Poly(I):poly(C12U) and CoQ10\u2009+\u2009NADH) and 5 non-pharmacological therapies (cognitive-behavior-therapy-related treatments, graded-exercise-related therapies, rehabilitation, acupuncture and abdominal tuina). However, there was no definitely effective intervention with coherence and reproducibility.<\/p>\n

Conclusions:<\/strong>
\nThis systematic review integrates the comprehensive features of previous RCTs for CFS\/ME and reflects on their limitations and perspectives in the process of developing new interventions.<\/p>\n","protected":false},"excerpt":{"rendered":"

Systematic review of randomized controlled trials for chronic fatigue syndrome\/ myalgic encephalomyelitis (CFS\/ME), by Do-Young Kim, Jin-Seok Lee, Samuel-Young Park, Soo-Jin Kim & Chang-Gue Son in Journal of Translational Medicine vol 18, no. 7 (2020)   Research abstract: Background: Although … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[5335,5576,5339,5577,5574,1806,5555,5575,5578],"class_list":["post-23840","post","type-post","status-publish","format-standard","hentry","category-news","tag-chang-gue-son","tag-do-young-kim","tag-jin-seok-lee","tag-randomised-controlled-trials","tag-rct","tag-research","tag-samuel-young-park","tag-soo-jin-kim","tag-systematic-review"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-6cw","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/23840","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=23840"}],"version-history":[{"count":6,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/23840\/revisions"}],"predecessor-version":[{"id":24144,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/23840\/revisions\/24144"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=23840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=23840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=23840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}