{"id":24500,"date":"2020-03-19T22:06:18","date_gmt":"2020-03-19T22:06:18","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=24500"},"modified":"2021-02-19T22:16:21","modified_gmt":"2021-02-19T22:16:21","slug":"can-the-light-of-immunometabolism-cut-through-brain-fog","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/can-the-light-of-immunometabolism-cut-through-brain-fog\/","title":{"rendered":"Can the light of immunometabolism cut through \u201cbrain fog\u201d?"},"content":{"rendered":"

Can the light of immunometabolism cut through \u201cbrain fog\u201d?<\/a> \u00a0by Mady Hornig in<\/span> J Clin Invest<\/em>. 2020;130(3):1102-1105 [doi.org\/10.1172\/JCI134985] First published February 10, 2020<\/h3>\n
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 <\/p>\n

Commentary abstract:<\/strong><\/h3>\n<\/div>\n

Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a highly debilitating disease with heterogeneous constitutional and neurological complaints. Infection-like symptoms often herald disease onset, but no pathogen or immune defect has been conclusively linked.<\/p>\n

In this issue of the JCI, Mandarano et al.<\/a> illuminate bioenergetic derangements of ME\/CFS T cell subsets. CD4+ and CD8+ T cells had impaired resting glycolysis. CD8+ cells additionally showed activation-related metabolic remodeling deficits and decreased mitochondrial membrane potential; a subset had increased resting mitochondrial mass.<\/p>\n

\"\"<\/p>\n

Immune senescence and exhaustion paradigms offer only partial explanations. Hence, unique mechanisms of disrupted immunometabolism<\/a> may underlie the complex neuroimmune dysfunction of ME\/CFS.<\/p>\n","protected":false},"excerpt":{"rendered":"

Can the light of immunometabolism cut through \u201cbrain fog\u201d? \u00a0by Mady Hornig in J Clin Invest. 2020;130(3):1102-1105 [doi.org\/10.1172\/JCI134985] First published February 10, 2020   Commentary abstract: Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a highly debilitating disease with heterogeneous constitutional and … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[6617,1344,2113],"class_list":["post-24500","post","type-post","status-publish","format-standard","hentry","category-news","tag-immunometabolism","tag-neuroimmune-dysfunction","tag-prof-mady-hornig"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-6na","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/24500","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=24500"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/24500\/revisions"}],"predecessor-version":[{"id":29873,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/24500\/revisions\/29873"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=24500"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=24500"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=24500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}