{"id":24823,"date":"2020-03-11T22:09:00","date_gmt":"2020-03-11T22:09:00","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=24823"},"modified":"2020-07-27T06:30:26","modified_gmt":"2020-07-27T06:30:26","slug":"cytomegalovirus-epstein%e2%80%90barr-virus-human-herpesvirus%e2%80%906-infections-in-patients-with-me-cfs-bulgaria","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/cytomegalovirus-epstein%e2%80%90barr-virus-human-herpesvirus%e2%80%906-infections-in-patients-with-me-cfs-bulgaria\/","title":{"rendered":"Cytomegalovirus, Epstein\u2010Barr virus, & human herpesvirus\u20106 infections in patients with ME\/CFS (Bulgaria)"},"content":{"rendered":"

Cytomegalovirus, Epstein\u2010Barr Virus and Human Herpesvirus 6 infections in patients with Myalgic \u0415ncephalomyelitis\/Chronic Fatigue Syndrome<\/a>, by Evelina Shikova, Valentina Reshkova, \u0410ntoniya Kumanova, Sevdalina Raleva,Dora Alexandrova, Natasa Capo, Modra Murovska ( on behalf of the European Network on ME\/CFS (EUROMENE) in<\/span> J Med Virol.<\/em>\u00a0 Mar 4 2020 [doi.org\/10.1002\/jmv.25744]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a disabling multisystem chronic disease. The etiology and pathogenesis of ME\/CFS are unknown. Infections of cytomegalovirus<\/a> (CMV), Epstein\u2010Barr virus<\/a> (EBV) and human herpesvirus\u20106<\/a> (HHV\u20106) are suspected as etiological agents for ME\/CFS.<\/p>\n

This study aims to estimate prevalence and type (active\/latent) of EBV, CMV and HHV\u20106 infections in Bulgarian ME\/CFS patients. In the study were included 58 ME\/CFS patients and 50 healthy controls.<\/p>\n

\"\"<\/a>Virus\u2010specific antibodies were detected by ELISA<\/a> and viral genomic sequences in PBMCs<\/a> and plasma samples \u2010 by nPCR. We did not observe any significant differences in virus specific IgG and IgM positivity rates between ME\/CFS patients and control group. In ME\/CFS plasma samples EBV DNA was found in 24.1%, CMV DNA \u2013 in 3.4% and HHV\u20106 DNA in 1.7% of samples. EBV DNA was detected in 4%, CMV and HHV\u20106 DNA were not found in plasma samples of controls.<\/p>\n

The frequency of viral genome detection in PBMCs of patients and controls was 74% vs 78% for CMV, 81% vs 84% for EBV, and 82.8% vs 82% for HHV\u20106. The difference in frequency of EBV active infection in ME\/CFS and control group was statistically significant (p=0.0027). No ME\/CFS and control individuals with active CMV and HHV\u20106 infection were observed.<\/p>\n

In conclusion<\/strong>, our study using both serological<\/a> and PCR\u2010based techniques for distinguishing between active and latent infection, showed high rate of active EBV infection among ME\/CFS patients indicating that at least in a subset of cases EBV is important factor for development of disease.<\/p>\n

 <\/p>\n

Simmaron research<\/strong>: Active Epstein-Barr Infections Found in Large ME\/CFS Study<\/a>, 18 Jul 2020<\/p>\n","protected":false},"excerpt":{"rendered":"

Cytomegalovirus, Epstein\u2010Barr Virus and Human Herpesvirus 6 infections in patients with Myalgic \u0415ncephalomyelitis\/Chronic Fatigue Syndrome, by Evelina Shikova, Valentina Reshkova, \u0410ntoniya Kumanova, Sevdalina Raleva,Dora Alexandrova, Natasa Capo, Modra Murovska ( on behalf of the European Network on ME\/CFS (EUROMENE) in … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[5705,5706,5709,5713,5707,5708,5712,221,224,220,225,2892,5714,5710,5711],"class_list":["post-24823","post","type-post","status-publish","format-standard","hentry","category-news","tag-cmv","tag-cytomegalovirus","tag-dr-dora-alexandrova","tag-dr-evelina-shikova","tag-dr-modra-murovskag","tag-dr-natasa-capo","tag-dr-valentina-reshkova","tag-ebv","tag-epstein-barr-virus","tag-hhv-6","tag-human-herpesvirus-6","tag-pbmc","tag-serological","tag-sevdalina-raleva","tag-ntoniya-kumanova"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-6sn","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/24823","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=24823"}],"version-history":[{"count":7,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/24823\/revisions"}],"predecessor-version":[{"id":27278,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/24823\/revisions\/27278"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=24823"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=24823"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=24823"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}