{"id":25172,"date":"2020-04-01T19:00:21","date_gmt":"2020-04-01T19:00:21","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=25172"},"modified":"2020-04-27T10:11:29","modified_gmt":"2020-04-27T10:11:29","slug":"human-leukocyte-antigen-alleles-associated-with-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/human-leukocyte-antigen-alleles-associated-with-me-cfs\/","title":{"rendered":"Human Leukocyte Antigen alleles associated with ME\/CFS"},"content":{"rendered":"

Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS), <\/a>by Asgeir Lande, \u00d8ystein Fluge, Elin B Strand, Siri T Fl\u00e5m, Daysi D Sosa, Olav Mella, Torstein Egeland, Ola D Saugsta, Benedicte A Lie, Marte K Viken in<\/span> Scientific Reports<\/em> vol 10, no. 5267, 24 March 2020<\/p>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

The etiology and pathogenesis of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) are unknown, and autoimmunity<\/a> is one of many proposed underlying mechanisms.\u00a0 Human Leukocyte Antigen<\/a> (HLA) associations are hallmarks of autoimmune disease, and have not been thoroughly investigated in a large ME\/CFS patient cohort.<\/p>\n

\"\"<\/a>We performed high resolution HLA -A, -B, -C, -DRB1, -DQB1 and -DPB1 genotyping<\/a> by next generation sequencing<\/a> in 426 adult, Norwegian ME\/CFS patients, diagnosed according to the Canadian Consensus Criteria<\/a>. HLA associations were assessed by comparing to 4511 healthy and ethnically matched controls. Clinical information was collected through questionnaires completed by patients or relatives.<\/p>\n

We discovered two independent HLA associations, tagged by the alleles HLA-C*07:04 (OR 2.1 [95% CI 1.4\u20133.1]) and HLA-DQB1*03:03 (OR 1.5 [95% CI 1.1\u20132.0]). These alleles<\/a> were carried by 7.7% and 12.7% of ME\/CFS patients, respectively. The proportion of individuals carrying one or both of these alleles was 19.2% in the patient group and 12.2% in the control group (OR 1.7 [95% CI 1.3\u20132.2], pnc\u2009=\u20090.00003).<\/p>\n

ME\/CFS is a complex disease, potentially with a substantial heterogeneity.<\/a> We report novel HLA associations pointing toward the involvement of the immune system in ME\/CFS pathogenesis.<\/p>\n

Comment:<\/strong> The best evidence yet that immune system problems can cause ME\/CFS?<\/a>, by Simon McGrath<\/p>\n","protected":false},"excerpt":{"rendered":"

Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS), by Asgeir Lande, \u00d8ystein Fluge, Elin B Strand, Siri T Fl\u00e5m, Daysi D Sosa, Olav Mella, Torstein Egeland, Ola D Saugsta, Benedicte A Lie, Marte K Viken in Scientific … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[1427,5750,5753,51,2387,1108,2984,4511,4512,5749,5751,1102,5754,5752],"class_list":["post-25172","post","type-post","status-publish","format-standard","hentry","category-news","tag-autoimmune-disorders","tag-benedicte-a-lie","tag-daysi-d-sosa","tag-dr-oystein-fluge","tag-elin-b-strand","tag-genes","tag-genotypes","tag-hla-genes","tag-human-leukocyte-antigen-molecules","tag-marte-k-viken","tag-ola-d-saugsta","tag-prof-olav-mella","tag-siri-t-flam","tag-torstein-egeland"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-6y0","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25172","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=25172"}],"version-history":[{"count":6,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25172\/revisions"}],"predecessor-version":[{"id":25681,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25172\/revisions\/25681"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=25172"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=25172"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=25172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}