{"id":25174,"date":"2020-06-05T07:25:54","date_gmt":"2020-06-05T07:25:54","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=25174"},"modified":"2020-06-05T07:25:54","modified_gmt":"2020-06-05T07:25:54","slug":"metabolic-dysfunction-in-me-cfs-not-due-to-anti-mitochondrial-antibodies","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/metabolic-dysfunction-in-me-cfs-not-due-to-anti-mitochondrial-antibodies\/","title":{"rendered":"Metabolic dysfunction in ME\/CFS not due to anti-mitochondrial antibodies"},"content":{"rendered":"

Metabolic dysfunction in myalgic encephalomyelitis\/chronic fatigue syndrome not due to anti-mitochondrial antibodies<\/a>, by Isabell Nilsson, Jeremy Palmer, Eirini Apostolou, Carl-Gerhard Gottfries, Muhammad Rizwan, Charlotte Dahle and Anders Ros\u00e9n\u00a0in<\/span> Front. Med<\/em>., 31 March 2020 [doi.org\/10.3389\/fmed.2020.00108 ]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

\"\"Metabolic profiling studies have recently indicated dysfunctional mitochondria<\/a> in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS). This includes an impaired function of pyruvate dehydrogenase complex<\/a> (PDC), possibly driven by serum factor(s), which leads to inadequate adenosine triphosphate generation<\/a> and excessive lactate<\/a> accumulation. A reminiscent energy blockade is likely to occur in primary biliary cholangitis <\/a>(PBC), caused by anti-PDC autoantibodies, as recently proposed. PBC is associated with fatigue and post-exertional malaise, also signifying ME\/CFS.<\/p>\n

We herein have investigated whether ME\/CFS patients have autoreactive antibodies<\/a> that could interfere with mitochondrial function. We found that only 1 of 161 examined ME\/CFS patients was positive for anti-PDC, while all PBC patients (15\/15) presented significant IgM, IgG, and IgA anti-PDC reactivity, as previously shown. None of fibromyalgia patients (0\/14), multiple sclerosis patients (0\/29), and healthy blood donors (0\/44) controls showed reactivities. Anti-mitochondrial autoantibodies (inner and outer membrane) were negative in ME\/CFS cohort. Anti-cardiolipin antibody levels in patients did not differ significantly from healthy blood donors.<\/p>\n

In conclusion, the impaired mitochondrial\/metabolic dysfunction, observed in ME\/CFS, cannot be explained by presence of circulating autoantibodies against the tested mitochondrial epitopes.<\/p>\n","protected":false},"excerpt":{"rendered":"

Metabolic dysfunction in myalgic encephalomyelitis\/chronic fatigue syndrome not due to anti-mitochondrial antibodies, by Isabell Nilsson, Jeremy Palmer, Eirini Apostolou, Carl-Gerhard Gottfries, Muhammad Rizwan, Charlotte Dahle and Anders Ros\u00e9n\u00a0in Front. Med., 31 March 2020 [doi.org\/10.3389\/fmed.2020.00108 ]   Research abstract: Metabolic profiling … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3283,4225,5939,5125,1560,5933,5936,115,5934,5935,168,4226,5937,1503,585,5938,3382],"class_list":["post-25174","post","type-post","status-publish","format-standard","hentry","category-news","tag-adenosine-triphosphate","tag-anders-rosen","tag-autoreactive-antibodies","tag-blood-lactate-accumulation","tag-carl-gerhard-gottfries","tag-charlotte-dahle","tag-eirini-apostolou","tag-fatigue","tag-isabell-nilsson","tag-jeremy-palmer","tag-mitochondrial-dysfunction","tag-muhammad-rizwan","tag-pbc","tag-pdcs","tag-post-exertional-malaise","tag-primary-biliary-cholngitis","tag-pyruvate-dehydrogenase"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-6y2","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=25174"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25174\/revisions"}],"predecessor-version":[{"id":26433,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25174\/revisions\/26433"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=25174"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=25174"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=25174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}