{"id":25288,"date":"2020-04-07T19:19:52","date_gmt":"2020-04-07T19:19:52","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=25288"},"modified":"2020-04-07T19:19:52","modified_gmt":"2020-04-07T19:19:52","slug":"systemic-hyperalgesia-in-females-with-gulf-war-illness-cfs-fm","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/systemic-hyperalgesia-in-females-with-gulf-war-illness-cfs-fm\/","title":{"rendered":"Systemic hyperalgesia in females with Gulf War Illness, CFS & FM"},"content":{"rendered":"

Systemic hyperalgesia in females with Gulf War Illness, Chronic Fatigue Syndrome and Fibromyalgia<\/a>, by Amber A Surian, James N Baraniuk in<\/span> Scientific Reports<\/em> vol 10, no.\u00a05751 (2020)<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

\"\"Pain is a diagnostic criterion for Gulf War Illness (GWI), Chronic Fatigue Syndrome (CFS), and fibromyalgia (FM). The physical sign of systemic hyperalgesia<\/a> (tenderness) was assessed in 920 women who were stratified by 2000 Kansas GWI, 1994 CFS, and 1990 FM criteria.<\/p>\n

Pressure was applied by dolorimetry<\/a> at 18 traditional tender points and the average pressure causing pain determined. GWI women were the most tender (2.9\u2009\u00b1\u20091.6\u2009kg, mean \u00b1 SD, n\u2009=\u200970), followed by CFS\/FM (3.1\u2009\u00b1\u20091.4\u2009kg, n\u2009=\u2009196), FM (3.9\u2009\u00b1\u20091.4\u2009kg, n\u2009=\u200956), and CFS (5.8\u2009\u00b1\u20092.1\u2009kg, n\u2009=\u2009170) compared to controls (7.2\u2009\u00b1\u20092.4\u2009kg, significantly highest by Mann-Whitney tests p\u2009<\u20090.0001, n\u2009=\u2009428).<\/p>\n

Receiver operating characteristics set pressure thresholds of 4.0\u2009kg to define GWI and CFS\/FM (specificity 0.85, sensitivities 0.80 and 0.83, respectively), 4.5\u2009kg for FM, and 6.0\u2009kg for CFS.<\/p>\n

Pain, fatigue, quality of life, and CFS symptoms were equivalent for GWI, CFS\/FM and CFS. Dolorimetry correlated with symptoms in GWI but not CFS or FM. Therefore, women with GWI, CFS and FM have systemic hyperalgesia compared to sedentary controls.<\/p>\n

The physical sign of tenderness may complement the symptoms of the Kansas criteria as a diagnostic criterion for GWI females, and aid in the diagnosis of CFS. Molecular mechanisms of systemic hyperalgesia may provide new insights into the neuropathology and treatments of these nociceptive<\/a>, interoceptive<\/a> and fatiguing illnesses.<\/p>\n","protected":false},"excerpt":{"rendered":"

Systemic hyperalgesia in females with Gulf War Illness, Chronic Fatigue Syndrome and Fibromyalgia, by Amber A Surian, James N Baraniuk in Scientific Reports vol 10, no.\u00a05751 (2020)   Research abstract: Pain is a diagnostic criterion for Gulf War Illness (GWI), … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[5772,5773,3894,251,252,845,846,4689,503],"class_list":["post-25288","post","type-post","status-publish","format-standard","hentry","category-news","tag-amber-a-surian","tag-dolorimetry","tag-dr-james-n-baraniuk","tag-fibromyalgia","tag-fm","tag-gulf-war-illness","tag-gwi","tag-hyperalgesia","tag-pain"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-6zS","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25288","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=25288"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25288\/revisions"}],"predecessor-version":[{"id":25330,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25288\/revisions\/25330"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=25288"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=25288"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=25288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}