{"id":25352,"date":"2020-04-17T07:07:07","date_gmt":"2020-04-17T07:07:07","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=25352"},"modified":"2021-07-13T09:51:23","modified_gmt":"2021-07-13T08:51:23","slug":"a-unifying-hypothesis-of-the-pathophysiology-of-me-cfs-recognitions-from-the-finding-of-autoantibodies-against-s2-adrenergic-receptors","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/a-unifying-hypothesis-of-the-pathophysiology-of-me-cfs-recognitions-from-the-finding-of-autoantibodies-against-s2-adrenergic-receptors\/","title":{"rendered":"A unifying hypothesis of the pathophysiology of ME\/CFS: recognitions from the finding of autoantibodies against \u00df2-adrenergic receptors"},"content":{"rendered":"

A unifying hypothesis of the pathophysiology of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS): recognitions from the finding of autoantibodies against \u00df2-adrenergic receptors<\/a>, by\u00a0Klaus Wirth, Carmen Scheibenbogen in<\/span> Autoimmunity Reviews, <\/em>online 1 April 2020 [doi.org\/10.1016\/j.autrev.2020.102527]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (CFS\/ME) is a complex and severely disabling disease with a prevalence of 0.3% and no approved treatment and therefore a very high medical need. Following an infectious onset patients suffer from severe central and muscle fatigue, chronic pain, cognitive impairment, and immune<\/a> and autonomic dysfunction<\/a>. Although the etiology of CFS\/ME is not solved yet, there is numerous evidence for an autoantibody mediated dysregulation of the immune and autonomic nervous system.<\/p>\n

\"\"We found elevated \u00df2 adrenergic receptor<\/a> (\u00df2AdR) and M3 acetylcholine receptor antibodies<\/a> in a subset of CFS\/ME patients. As both \u00df2AdR and M3 acetylcholine receptor are important vasodilators, we would expect their functional disturbance to result in vasoconstriction<\/a> and hypoxemia<\/a>. An impaired circulation and oxygen supply could result in many symptoms of ME\/CFS. There are consistent reports of vascular dysfunction in ME\/CFS. Muscular and cerebral hypoperfusion<\/a> has been shown in ME\/CFS in various studies and correlated with fatigue. Metabolic<\/a> changes in ME\/CFS are also in line with a concept of hypoxia and ischemia.<\/p>\n

Here we try to develop a unifying working concept for the complex pathomechanism of ME\/CFS based on the presence of dysfunctional autoantibodies<\/a> against \u00df2AdR and M3 acetylcholine receptor and extrapolate it to the pathophysiology of ME\/CFS without an autoimmune pathogenesis.<\/p>\n

 <\/p>\n

Health rising:<\/strong> Hypothesis predicts major failure point in Chronic Fatigue Syndrome (ME\/CFS)<\/a><\/p>\n

Simmaron Research<\/strong>: The blood vessel crunch: a unifying hypothesis for ME\/CFS<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A unifying hypothesis of the pathophysiology of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS): recognitions from the finding of autoantibodies against \u00df2-adrenergic receptors, by\u00a0Klaus Wirth, Carmen Scheibenbogen in Autoimmunity Reviews, online 1 April 2020 [doi.org\/10.1016\/j.autrev.2020.102527]   Research abstract: Myalgic Encephalomyelitis or Chronic … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3652,2064,1427,4267,5805,5804,5802,5803,5806],"class_list":["post-25352","post","type-post","status-publish","format-standard","hentry","category-news","tag-abnormal-blood-circulation","tag-autoantibodies","tag-autoimmune-disorders","tag-carmen-scheibenbogen","tag-klaus-wirth","tag-m3-acetylcholine-receptor","tag-s2-adrenergic-receptor","tag-s2adr","tag-vascular-dysfunction"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-6AU","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25352","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=25352"}],"version-history":[{"count":6,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25352\/revisions"}],"predecessor-version":[{"id":31894,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25352\/revisions\/31894"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=25352"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=25352"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=25352"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}