{"id":25563,"date":"2020-04-20T21:42:48","date_gmt":"2020-04-20T21:42:48","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=25563"},"modified":"2020-04-20T21:43:14","modified_gmt":"2020-04-20T21:43:14","slug":"processing-of-laser-evoked-potentials-in-patients-with-chronic-whiplash-associated-disorders-cfs-healthy-controls-a-case-control-study","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/processing-of-laser-evoked-potentials-in-patients-with-chronic-whiplash-associated-disorders-cfs-healthy-controls-a-case-control-study\/","title":{"rendered":"Processing of Laser-Evoked Potentials in patients with Chronic Whiplash-Associated Disorders, CFS & healthy controls: a case\u2013control study"},"content":{"rendered":"

Processing of Laser-Evoked Potentials in pa<\/span>tients with Chronic Whiplash-Associated Disorders, Chronic Fatigue Syndrome, and healthy controls<\/a>: a case\u2013control study, by Lisa Goudman, PhD, Liesbeth Daenen, PhD, Andre Mouraux, PhD, Jo Nijs, PhD, Patrick Cras, PhD, Nathalie Roussel, PhD, Maarten Moens, PhD, Iris Coppieters, PhD, Eva Huysmans, MSc, Margot De Kooning, PhD in<\/span> Pain Medicine,<\/em> 14 April 2020 [https:\/\/doi.org\/10.1093\/pm\/pnaa068]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Objective<\/strong>
\nLaser-evoked potentials<\/a>\"\"<\/a> (LEPs) are among the reliable neurophysiological tools to investigate patients with neuropathic pain, as they can provide an objective account of the functional status of thermo-nociceptive pathways. The goal of this study was to explore the functioning of the nociceptive afferent pathways<\/a> by examining LEPs in patients with chronic whiplash-associated disorders<\/a> (cWAD), patients with chronic fatigue syndrome (CFS), and healthy controls (HCs).<\/p>\n

Design<\/strong>
\nCase\u2013control study.<\/p>\n

Setting<\/strong>
\nA single medical center in Belgium.<\/p>\n

Subjects<\/strong>
\nThe LEPs of 21 patients with cWAD, 19 patients with CFS, and 18 HCs were analyzed in this study.<\/p>\n

Methods<\/strong>
\nAll participants received brief nociceptive CO2 laser stimuli applied to the dorsum of the left hand and left foot while brain activity was recorded with a 32-channel electroencephalogram<\/a> (EEG). LEP signals and transient power modulations were compared between patient groups and HCs.<\/p>\n

Results<\/strong>
\nNo between-group differences were found for stimulus intensity, which was supraliminal<\/a> for A\u03b4 fibers. The amplitudes and latencies of LEP wave components N1, N2, and P2 in patients with cWAD and CFS were statistically similar to those of HCs. There were no significant differences between the time\u2013frequency maps of EEG oscillation amplitude between HCs and both patient populations.<\/p>\n

Conclusions<\/strong>
\nEEG responses of heat-sensitive A\u03b4 fibers in patients with cWAD and CFS revealed no significant differences from the responses of HCs. These findings thus do not support a state of generalized central nervous system<\/a> hyperexcitability in those patients.<\/p>\n

Read full paper<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Processing of Laser-Evoked Potentials in patients with Chronic Whiplash-Associated Disorders, Chronic Fatigue Syndrome, and healthy controls: a case\u2013control study, by Lisa Goudman, PhD, Liesbeth Daenen, PhD, Andre Mouraux, PhD, Jo Nijs, PhD, Patrick Cras, PhD, Nathalie Roussel, PhD, Maarten Moens, … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[230,5827,5828,2415,2416,5830,5829,2143],"class_list":["post-25563","post","type-post","status-publish","format-standard","hentry","category-news","tag-central-nervous-system","tag-chronic-whiplash-associated-disorders","tag-cwad","tag-eeg","tag-electroencephalogram","tag-laser-evoked-potentials","tag-lep","tag-prof-jo-nijs"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-6Ej","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25563","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=25563"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25563\/revisions"}],"predecessor-version":[{"id":25616,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25563\/revisions\/25616"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=25563"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=25563"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=25563"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}