{"id":25591,"date":"2020-04-22T05:14:01","date_gmt":"2020-04-22T05:14:01","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=25591"},"modified":"2020-04-22T05:14:01","modified_gmt":"2020-04-22T05:14:01","slug":"autoimmunity-related-risk-variants-in-ptpn22-ctla4-are-associated-with-me-cfs-with-infectious-onset","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/autoimmunity-related-risk-variants-in-ptpn22-ctla4-are-associated-with-me-cfs-with-infectious-onset\/","title":{"rendered":"Autoimmunity-related risk variants in PTPN22 & CTLA4 are associated with ME\/CFS with infectious onset"},"content":{"rendered":"

Autoimmunity-related risk variants in PTPN22 and CTLA4 are associated with ME\/CFS with infectious onset<\/a>,\u00a0by Sophie Steiner, Sonya C Becker, Jelka Hartwig, Franziska Sotzny, Sebastian Lorenz, Sandra Bauer, Madlen L\u00f6bel, Anna B Stittrich, Patricia Grabowski and Carmen Scheibenbogen in<\/span> Front. Immunol.,<\/em> 09 April 2020[doi.org\/10.3389\/fimmu.2020.00578]<\/a><\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n
\"\"

SNP model by David Eccles, Wiki commons<\/p><\/div>\n

Single nucleotide polymorphisms<\/a> (SNP) in various genes have been described to be associated with susceptibility to autoimmune disease<\/a>.<\/p>\n

In this study, myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) patients and controls were genotyped for five immune gene SNPs in tyrosine phosphatase non-receptor type 22 (PTPN22, rs2476601), cytotoxic T-lymphocyte-associated protein 4 (CTLA4, rs3087243), tumor necrosis factor (TNF, rs1800629 and rs1799724), and interferon regulatory factor 5 (IRF5, rs3807306), which are among the most important risk variants for autoimmune diseases.<\/p>\n

Analysis of 305 ME\/CFS patients and 201 healthy controls showed significant associations of the PTPN22 rs2476601 and CTLA4 rs3087243 autoimmunity-risk alleles with ME\/CFS. The associations were only found in ME\/CFS patients, who reported an acute onset of disease with an infection (PTPN22 rs2476601: OR 1.63, CI 1.04\u20132.55, p = 0.016; CTLA4 rs3087243: OR 1.53, CI 1.17\u20132.03, p = 0.001), but not in ME\/CFS patients without infection-triggered onset (PTPN22 rs2476601: OR 1.09, CI 0.56\u20132.14, p = 0.398; CTLA4 rs3087243: OR 0.89, CI 0.61\u20131.30, p = 0.268).<\/p>\n

This finding provides evidence that autoimmunity might play a role in ME\/CFS with an infection-triggered onset. Both genes play a key role in regulating B and T cell activation<\/a>.<\/p>\n

Meet The Researchers: Carmen Scheibenbogen<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Autoimmunity-related risk variants in PTPN22 and CTLA4 are associated with ME\/CFS with infectious onset,\u00a0by Sophie Steiner, Sonya C Becker, Jelka Hartwig, Franziska Sotzny, Sebastian Lorenz, Sandra Bauer, Madlen L\u00f6bel, Anna B Stittrich, Patricia Grabowski and Carmen Scheibenbogen in Front. Immunol., … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[5831,1427,4267,4577,1108,5640,5832,4268,4575,5727,1741,1186,5833,5834,4982],"class_list":["post-25591","post","type-post","status-publish","format-standard","hentry","category-news","tag-anna-b-stittrich","tag-autoimmune-disorders","tag-carmen-scheibenbogen","tag-franziska-sotzny","tag-genes","tag-jelka-hartwig","tag-madlen-lobel","tag-patricia-grabowski","tag-sandra-bauer","tag-sebastian-lorenz","tag-single-nucleotide-polymorphisms","tag-snps","tag-sonya-c-becker","tag-sophie-steiner","tag-t-cell-activation"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-6EL","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25591","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=25591"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25591\/revisions"}],"predecessor-version":[{"id":25624,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25591\/revisions\/25624"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=25591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=25591"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=25591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}