{"id":25669,"date":"2020-04-24T00:53:45","date_gmt":"2020-04-24T00:53:45","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=25669"},"modified":"2020-04-24T00:53:45","modified_gmt":"2020-04-24T00:53:45","slug":"potential-role-of-microbiome-in-cfs-me","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/potential-role-of-microbiome-in-cfs-me\/","title":{"rendered":"Potential role of microbiome in CFS\/ME"},"content":{"rendered":"

Potential role of microbiome in Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis (CFS\/ME),<\/a> by Guiseppe Lupo. PhD thesis, Universit\u00e0 Cattolica del Sacro Cuore, \u00a0XXXII ciclo, a.a. 2018\/19, Piacenza,\u00a08 April 2020<\/h3>\n

\u00a0<\/strong><\/p>\n

Research abstract:<\/strong><\/p>\n

The Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis (CFS\/ME), is a severe multisystemic disease characterized by immunological abnormalities and dysfunction of energy metabolism. Recent evidence suggest that there is a strong correlation between dysbiosis<\/a> and pathological<\/a> condition.<\/p>\n

The present research investigated the composition of the intestinal and oral microbiota in CFS\/ME patients in comparison to healthy controls and determined whether any observed differences could be useful for the identification of diagnostic biomarkers. The fecal and salivary bacterial composition in CFS\/ME patients was investigated by Illumina sequencing of 16S rRNA gene amplicons.<\/p>\n

\"\"The fecal microbiota of CFS\/ME patients showed a significant reduction of Lachnospiraceae<\/a>, particularly Anaerostipes<\/a>, compared to the non-CFS\/ME groups, and an increase of Phascolarctobacterium faecium and unclassified Ruminococcus. Bacteroides vulgatus, unclassified Bacteroides, Bacteroides uniformis and unclassified Barnesiella resulted significantly more abundant in CFS\/ME patients. The oral microbiota of CFS\/ME patients showed a significant increase of Rothia dentocariosa. The fecal metabolic profile of a subgroup of CFS\/ME patients revealed an overall increase of SCFAs and indole derivatives compared to the non-CFS\/ME groups, suggesting an increase in the fermentation processes.<\/p>\n

Our results support the autoimmune hypothesis for CFS\/ME condition and if confirmed by larger studies, the differences detected in the microbial profiles of CFS\/ME patients may be used as markers for a more accurate diagnosis and for the development of specific therapeutic strategies.<\/p>\n

Read more<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Potential role of microbiome in Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis (CFS\/ME), by Guiseppe Lupo. PhD thesis, Universit\u00e0 Cattolica del Sacro Cuore, \u00a0XXXII ciclo, a.a. 2018\/19, Piacenza,\u00a08 April 2020 \u00a0 Research abstract: The Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis (CFS\/ME), is a severe multisystemic … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3721,5842,2334,4749],"class_list":["post-25669","post","type-post","status-publish","format-standard","hentry","category-news","tag-faecalibacterium","tag-guiseppe-lupo","tag-microbiodata","tag-microbiome"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-6G1","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25669","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=25669"}],"version-history":[{"count":1,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25669\/revisions"}],"predecessor-version":[{"id":25670,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25669\/revisions\/25670"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=25669"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=25669"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=25669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}