{"id":25682,"date":"2020-04-27T19:46:57","date_gmt":"2020-04-27T19:46:57","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=25682"},"modified":"2020-08-17T09:02:10","modified_gmt":"2020-08-17T09:02:10","slug":"human-herpesvirus-6-reactivation-mitochondrial-fragmentation-the-coordination-of-antiviral-metabolic-phenotypes-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/human-herpesvirus-6-reactivation-mitochondrial-fragmentation-the-coordination-of-antiviral-metabolic-phenotypes-in-me-cfs\/","title":{"rendered":"Human Herpesvirus-6 reactivation, mitochondrial fragmentation, & the coordination of antiviral & metabolic phenotypes in ME\/CFS"},"content":{"rendered":"

Human Herpesvirus-6 reactivation, mitochondrial fragmentation, and the coordination of antiviral and metabolic phenotypes in Myalgic Encephalomyelitis\/ Chronic Fatigue Syndrome<\/a>, by Philipp Schreiner, Thomas Harrer, Carmen Scheibenbogen, Stephanie Lamer, Andreas Schlosser, Robert K Naviaux and Bhupesh K Prusty in<\/span> ImmunoHorizons<\/em> April 1, 2020, 4 (4) 201-215 [doi.org\/10.4049]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a multifactorial disorder with many possible triggers. Human herpesvirus (HHV)\u20136 and HHV-7 are two infectious triggers for which evidence has been growing.<\/p>\n

To understand possible causative role of HHV-6<\/a> in ME\/CFS, metabolic and antiviral phenotypes of U2-OS cells<\/a> were studied with and without chromosomally integrated HHV-6 and with or without virus reactivation using the histone deacetylase inhibitor trichostatin-A.<\/p>\n

Proteomic analysis<\/a> was conducted by pulsed stable isotope labeling by amino acids in cell culture analysis. Antiviral properties that were induced by HHV-6 transactivation were studied in virus-naive A549 cells challenged by infection with influenza-A (H1N1) or HSV-1.<\/p>\n

Mitochondria were fragmented and 1-carbon metabolism, dUTPase, and thymidylate synthase were strongly induced by HHV-6 reactivation, whereas superoxide dismutase 2 and proteins required for mitochondrial oxidation of fatty acid, amino acid, and glucose metabolism, including pyruvate dehydrogenase, were strongly inhibited.<\/p>\n

Adoptive transfer of U2-OS cell supernatants after reactivation of HHV-6A led to an antiviral state in A549 cells that prevented superinfection with influenza-A and HSV-1. Adoptive transfer of serum from 10 patients with ME\/CFS produced a similar fragmentation of mitochondria and the associated antiviral state in the A549 cell assay.<\/p>\n

\"\"

Antiviral-immunity-in-ME\/CFS (BK Prusty<\/p><\/div>\n

In conclusion, HHV-6 reactivation in ME\/CFS patients activates a multisystem, proinflammatory, cell danger response<\/a> that protects against certain RNA and DNA virus infections but comes at the cost of mitochondrial fragmentation<\/a> and severely compromised energy metabolism.<\/a><\/p>\n

Comment<\/strong> by Cort Johnson: Explaining ME\/CFS? Prusty \/ Naviaux Study Ties Infections to Energy Breakdowns<\/a><\/p>\n

EurekAlert<\/strong>: For ME\/CFS patients, viral immunities come at a devastating, lifelong cost<\/a><\/p>\n

UCSDSNews:<\/strong> For ME\/CFS Patients, Viral Immunities Come at a Devastating, Lifelong Cost<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Human Herpesvirus-6 reactivation, mitochondrial fragmentation, and the coordination of antiviral and metabolic phenotypes in Myalgic Encephalomyelitis\/ Chronic Fatigue Syndrome, by Philipp Schreiner, Thomas Harrer, Carmen Scheibenbogen, Stephanie Lamer, Andreas Schlosser, Robert K Naviaux and Bhupesh K Prusty in ImmunoHorizons April … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[5853,4650,4267,4572,220,835,168,5851,5223,5852,4649],"class_list":["post-25682","post","type-post","status-publish","format-standard","hentry","category-news","tag-andreas-schlosser","tag-bhupesh-k-prusty","tag-carmen-scheibenbogen","tag-cell-danger-response","tag-hhv-6","tag-human-herpes-virus-6","tag-mitochondrial-dysfunction","tag-philipp-schreiner","tag-robert-k-naviaux","tag-stephanie-lamer","tag-thomas-harrer"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-6Ge","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=25682"}],"version-history":[{"count":7,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25682\/revisions"}],"predecessor-version":[{"id":27627,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/25682\/revisions\/27627"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=25682"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=25682"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=25682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}