{"id":26696,"date":"2020-08-04T07:43:15","date_gmt":"2020-08-04T07:43:15","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=26696"},"modified":"2020-08-04T07:43:15","modified_gmt":"2020-08-04T07:43:15","slug":"inclusion-of-family-members-without-me-cfs-in-research-studies-promotes-discovery-of-biomarkers-specific-for-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/inclusion-of-family-members-without-me-cfs-in-research-studies-promotes-discovery-of-biomarkers-specific-for-me-cfs\/","title":{"rendered":"Inclusion of family members without ME\/CFS in research studies promotes discovery of biomarkers specific for ME\/CFS"},"content":{"rendered":"

Inclusion of family members without ME\/CFS in research studies promotes discovery of biomarkers specific for ME\/CFS<\/a>, by \u00a0in<\/span>\u00a0Work<\/em> 2020 [DOI: 10.3233\/WOR-203177]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

BACKGROUND:<\/strong><\/p>\n

The search for a biomarker<\/a> specific for ME\/CFS (myalgic encephalomyelitis\/chronic fatigue syndrome) has been long, arduous and, to date, unsuccessful. Researchers need to consider their expenditures on each new candidate biomarker. In a previous study of antibody-dependent cell-mediated cytotoxicity<\/a> (ADCC) by natural killer lymphocytes<\/a>, we found lower ADCC for ME\/CFS patients vs. unrelated donors but ruled against low ADCC as a biomarker because of similar ADCC for patients vs. their family members without ME\/CFS.<\/p>\n

OBJECTIVE:<\/strong><\/p>\n

\"\"We applied inclusion of family members without ME\/CFS, from families with multiple CFS patients, as a second non-ME\/CFS control group in order to re-examine inflammation<\/a> in ME\/CFS.<\/p>\n

METHOD:<\/strong><\/p>\n

Total and CD16A-positive<\/a> \u2018non-classical\u2019 anti-inflammatory monocytes<\/a> were monitored.<\/p>\n

RESULTS<\/strong>:<\/p>\n

Non-classical monocytes were elevated for patients vs. unrelated healthy donors but these differences were insignificant between patients vs. unaffected family members.<\/p>\n

CONCLUSIONS:<\/strong><\/p>\n

Inclusion of family members ruled against biomarker considerations for the monocytes characterized. These pilot findings for the non-classical monocytes are novel in the field of ME\/CFS. We recommend that occupational therapists advocate and explain to family members without ME\/CFS the need for the family members\u2019 participation as a second set of controls in pilot studies to rapidly eliminate false biomarkers, optimize patient antibody-dependent cell-mediated cytotoxicity participation, and save researchers\u2019 labor.<\/p>\n","protected":false},"excerpt":{"rendered":"

Inclusion of family members without ME\/CFS in research studies promotes discovery of biomarkers specific for ME\/CFS, by \u00a0in\u00a0Work 2020 [DOI: 10.3233\/WOR-203177]   Research abstract: BACKGROUND: The search for a biomarker specific for ME\/CFS (myalgic encephalomyelitis\/chronic fatigue syndrome) has been long, … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[1771,1770,6112,4170,6107,6108,59,6109,6111,6113,6110],"class_list":["post-26696","post","type-post","status-publish","format-standard","hentry","category-news","tag-adcc","tag-antibody-dependent-cell-mediated-cytotoxicity","tag-ap-sung","tag-biomarker","tag-d-hudig","tag-d-redelman","tag-dr-lucinda-bateman","tag-j-smith-gagen","tag-jj-tang","tag-k-tokunaga","tag-mj-guglielmo"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-6WA","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/26696","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=26696"}],"version-history":[{"count":7,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/26696\/revisions"}],"predecessor-version":[{"id":27405,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/26696\/revisions\/27405"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=26696"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=26696"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=26696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}