{"id":26916,"date":"2020-07-14T06:14:59","date_gmt":"2020-07-14T06:14:59","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=26916"},"modified":"2020-07-14T06:14:59","modified_gmt":"2020-07-14T06:14:59","slug":"two-day-cardiopulmonary-exercise-testing-in-females-with-a-severe-grade-of-me-cfs-comparison-with-patients-with-mild-moderate-disease","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/two-day-cardiopulmonary-exercise-testing-in-females-with-a-severe-grade-of-me-cfs-comparison-with-patients-with-mild-moderate-disease\/","title":{"rendered":"Two-Day cardiopulmonary exercise testing in females with a severe grade of ME\/CFS: comparison with patients with mild & moderate disease"},"content":{"rendered":"

Two-Day cardiopulmonary exercise testing in females with a severe grade of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: comparison with patients with mild and moderate diseas<\/a>e, by\u00a0 C (Linda) MC van Campen, Peter C Rowe and Frans C Visser in<\/span> Healthcare<\/em> 2020, 8(3), 192; [doi.org\/10.3390\/healthcare8030192] ne 2020
\n(This article belongs to the Special Issue\u00a0ME\/CFS \u2013 the Severely and Very Severely Affected<\/em>)<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Introduction:<\/strong><\/p>\n

Effort intolerance along with a prolonged recovery from exercise and post-exertional exacerbation of symptoms are characteristic features of myalgic encephalomyelitis\/ chronic fatigue syndrome (ME\/CFS). The gold standard to measure the degree of physical activity intolerance is cardiopulmonary exercise testing<\/a> (CPET).<\/p>\n

Multiple studies have shown that peak oxygen consumption<\/a> is reduced in the majority of ME\/CFS patients, and that a 2-day CPET protocol further discriminates between ME\/CFS patients and sedentary controls.<\/p>\n

Limited information is present on ME\/CFS patients with a severe form of the disease. Therefore, the aim of this study was to compare the effects of a 2-day CPET protocol in female ME\/CFS patients with a severe grade of the disease to mildly and moderately affected ME\/CFS patients.<\/p>\n

Methods and results: <\/strong><\/p>\n

\"\"We studied 82 female patients who had undergone a 2-day CPET protocol. Measures of oxygen consumption (VO2), heart rate (HR) and workload both at peak exercise and at the ventilatory threshold<\/a> (VT) were collected. ME\/CFS disease severity was graded according to the International Consensus Criteria<\/a>.<\/p>\n

Thirty-one patients were clinically graded as having mild disease, 31 with moderate and 20 with severe disease. Baseline characteristics did not differ between the 3 groups. Within each severity group, all analyzed CPET parameters (peak VO2, VO2 at VT, peak workload and the workload at VT) decreased significantly from day-1 to day-2 (p-Value between 0.003 and <0.0001).<\/p>\n

The magnitude of the change in CPET parameters from day-1 to day-2 was similar between mild, moderate, and severe groups, except for the difference in peak workload between mild and severe patients (p = 0.019). The peak workload decreases from day-1 to day-2 was largest in the severe ME\/CFS group (\u221219 (11) %).<\/p>\n

Conclusion: <\/strong><\/p>\n

This relatively large 2-day CPET protocol study confirms previous findings of the reduction of various exercise variables in ME\/CFS patients on day-2 testing. This is the first study to demonstrate that disease severity negatively influences exercise capacity in female ME\/CFS patients. Finally, this study shows that the deterioration in peak workload from day-1 to day-2 is largest in the severe ME\/CFS patient group.<\/p>\n","protected":false},"excerpt":{"rendered":"

Two-Day cardiopulmonary exercise testing in females with a severe grade of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: comparison with patients with mild and moderate disease, by\u00a0 C (Linda) MC van Campen, Peter C Rowe and Frans C Visser in Healthcare 2020, 8(3), … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3049,516,4006,3591,4007,36,6058,4767],"class_list":["post-26916","post","type-post","status-publish","format-standard","hentry","category-news","tag-2-day-cpet","tag-cardiopulmonary-exercise-testing","tag-dr-linda-van-campen","tag-dr-peter-rowe","tag-prof-hans-visser","tag-severe-me","tag-vo2-vt","tag-vo2peak"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-708","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/26916","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=26916"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/26916\/revisions"}],"predecessor-version":[{"id":27056,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/26916\/revisions\/27056"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=26916"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=26916"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=26916"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}