{"id":26918,"date":"2020-07-13T08:44:59","date_gmt":"2020-07-13T08:44:59","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=26918"},"modified":"2020-07-13T08:45:39","modified_gmt":"2020-07-13T08:45:39","slug":"altered-structural-brain-networks-related-to-adrenergic-muscarinic-receptor-autoantibodies-in-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/altered-structural-brain-networks-related-to-adrenergic-muscarinic-receptor-autoantibodies-in-cfs\/","title":{"rendered":"Altered structural brain networks related to adrenergic\/muscarinic receptor autoantibodies in CFS"},"content":{"rendered":"

Altered structural brain networks related to adrenergic\/muscarinic receptor autoantibodies in Chronic Fatigue Syndrome<\/a>, by Hiroyuki Fujii, Wakiro Sato, YukioKimura, Hiroshi Matsuda, Miho Ota, Norihide Maikusa, Fumio Suzuki, Keiko Amano Isu Shin, Takashi Yamamura, Harushi Mori, Noriko Sato in<\/span> Journal of Neuroimaging<\/em> \u00b7 July 2020 [doi.org\/10.1111\/jon.12751]<\/h3>\n

 <\/p>\n

Research Abstract:<\/strong><\/h3>\n

BACKGROUND AND PURPOSE<\/strong>
\nRecent studies suggest that the autoantibodies against adrenergic\/muscarinic receptors<\/a> might be one of the causes and potential markers of myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS). The purpose of this study was to investigate the structural network changes related to autoantibody titers<\/a> against adrenergic\/muscarinic receptors in ME\/CFS by performing a single\u2010subject gray matter<\/a> similarity\u2010based structural network analysis.<\/p>\n

METHODS<\/strong>
\nWe prospectively examined 89 consecutive right\u2010handed ME\/CFS patients who underwent both brain MRI<\/a> including 3D T1\u2010wighted images and a blood analysis of autoantibodies titers against \u03b21 adrenergic receptor (\u03b21 AdR\u2010Ab), \u03b22 AdR\u2010Ab, M3 acetylcholine receptor (M3 AchR\u2010Ab), and M4 AchR\u2010Ab. Single\u2010subject gray matter similarity\u2010based structural networks<\/a> were extracted from segmented gray matter images for each patient. We calculated local network properties (betweenness centrality, clustering coefficient, and characteristic path length) and global network properties (normalized path length \u03bb, normalized clustering coefficient \u03b3, and small\u2010world network value \u03b4). We investigated the correlations between the autoantibody titers and regional gray matter\/white matter volumes, the local network properties, and the global network properties.<\/p>\n

RESULTS<\/strong><\/p>\n

\"\"

Dorsolateral Prefrontal Cortex<\/p><\/div>\n

Betweenness centrality<\/a> showed a significant positive correlation with \u03b21\u2010AdR\u2010Ab<\/a> in the right dorsolateral prefrontal cortex<\/a>. The characteristic path length showed a significant negative correlation with \u03b22\u2010AdR\u2010Ab<\/a> in the right precentral gyrus<\/a>. There were no significant correlations between the antibody titers and the regional gray matter\/white matter volumes, and the global network properties.<\/p>\n

CONCLUSIONS<\/strong>
\nOur findings suggest that \u03b21 AdR\u2010Ab and \u03b22 AdR\u2010Ab are potential markers of ME\/CFS.<\/p>\n

 <\/p>\n

Read full article<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Altered structural brain networks related to adrenergic\/muscarinic receptor autoantibodies in Chronic Fatigue Syndrome, by Hiroyuki Fujii, Wakiro Sato, YukioKimura, Hiroshi Matsuda, Miho Ota, Norihide Maikusa, Fumio Suzuki, Keiko Amano Isu Shin, Takashi Yamamura, Harushi Mori, Noriko Sato in Journal of … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[6054,3415,6044,6047,6050,6053,6043,6046,1037,6045,6049,6048,6051,6052],"class_list":["post-26918","post","type-post","status-publish","format-standard","hentry","category-news","tag-adrb2","tag-adrenergic-receptors","tag-fumio-suzuki","tag-hiroshi-matsuda","tag-hiroyuki-fujii","tag-https-en-wikipedia-org-wiki-beta-2_adrenergic_receptor","tag-keiko-amano","tag-miho-ota","tag-mri","tag-norihide-maikusa","tag-wakiro-sato","tag-yukio-kimura","tag-1adrab","tag-2adrab"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-70a","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/26918","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=26918"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/26918\/revisions"}],"predecessor-version":[{"id":27036,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/26918\/revisions\/27036"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=26918"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=26918"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=26918"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}