{"id":27393,"date":"2020-08-04T23:20:52","date_gmt":"2020-08-04T23:20:52","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=27393"},"modified":"2020-08-04T23:20:52","modified_gmt":"2020-08-04T23:20:52","slug":"me-cfs-efficacy-of-repeat-immunoadsorption","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/me-cfs-efficacy-of-repeat-immunoadsorption\/","title":{"rendered":"ME\/CFS: efficacy of repeat immunoadsorption"},"content":{"rendered":"

Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: efficacy of repeat Immunoadsorption<\/a>, by\u00a0 Markus T\u00f6lle, Helma Freitag, Michaela Antelmann, Jelka Hartwig, Mirjam Schuchardt, Markus van der Giet, Kai-Uwe Eckardt, Patricia Grabowski, and Carmen Scheibenbogen in<\/span> J. Clin. Med.<\/em> 2020, 9(8), 2443; [doi.org\/10.3390\/jcm9082443] Published: 30 July 2020<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

(1) Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) is a complex neuroimmunological disease.<\/p>\n

\"\"There is evidence for an autoimmune mechanism for ME\/CFS with an infection-triggered onset and dysfunction of \u00df2-adrenoreceptor antibodies<\/a> (\u00df2AR-AB). In a first proof-of-concept study, we could show that IA<\/a> was effective to reduce \u00df2AR-AB and led to improvement of various symptoms. (2)<\/p>\n

Five of the ME\/CFS patients who had clinical improvement following treatment with a five-day IA were retreated in the current study about two years later with a modified IA protocol. The severity of symptoms was assessed by disease specific scores during a follow-up period of 12 months. The antibodies were determined by ELISA<\/a>. (3)<\/p>\n

The modified IA treatment protocol resulted in a remarkable similar clinical response. The treatment was well tolerated and 80\u201390% decline of total IgG and \u00df2AR-AB was achieved. Four patients showed a rapid improvement in several clinical symptoms during IA therapy, lasting for six to 12 months. One patient had no improvement. (4)<\/p>\n

We could provide further evidence that IA has clinical efficacy in patients with ME\/CFS. Data from our pilot trial warrant further controlled studies in ME\/CFS.<\/p>\n","protected":false},"excerpt":{"rendered":"

Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: efficacy of repeat Immunoadsorption, by\u00a0 Markus T\u00f6lle, Helma Freitag, Michaela Antelmann, Jelka Hartwig, Mirjam Schuchardt, Markus van der Giet, Kai-Uwe Eckardt, Patricia Grabowski, and Carmen Scheibenbogen in J. Clin. Med. 2020, 9(8), 2443; [doi.org\/10.3390\/jcm9082443] Published: 30 … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4267,6120,4266,5640,6115,6119,6116,6118,6117,4268,6114,6121],"class_list":["post-27393","post","type-post","status-publish","format-standard","hentry","category-news","tag-carmen-scheibenbogen","tag-helma-freitag","tag-immunoadsorption","tag-jelka-hartwig","tag-kai-uwe-eckardt","tag-markus-tolle","tag-markus-van-der-giet","tag-michaela-antelmann","tag-mirjam-schuchardt","tag-patricia-grabowski","tag-s2-adrenoreceptor-autoantibody","tag-s2ar-ab"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-77P","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/27393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=27393"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/27393\/revisions"}],"predecessor-version":[{"id":27416,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/27393\/revisions\/27416"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=27393"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=27393"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=27393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}