{"id":27524,"date":"2020-08-10T07:03:40","date_gmt":"2020-08-10T07:03:40","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=27524"},"modified":"2020-08-10T07:03:40","modified_gmt":"2020-08-10T07:03:40","slug":"genetic-risk-factors-of-me-cfs-a-critical-review","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/genetic-risk-factors-of-me-cfs-a-critical-review\/","title":{"rendered":"Genetic risk factors of ME\/CFS: a critical review"},"content":{"rendered":"<h3><a href=\"https:\/\/academic.oup.com\/hmg\/advance-article\/doi\/10.1093\/hmg\/ddaa169\/5879704\" target=\"_blank\" rel=\"noopener noreferrer\">Genetic risk factors of ME\/CFS: a critical review<\/a>, by <span style=\"text-decoration: underline;\">in<\/span> <em>Human Molecular Genetics<\/em>, ddaa169, 3 Aug 2020 [doi.org\/10.1093\/hmg\/ddaa169]<\/h3>\n<p>&nbsp;<\/p>\n<h3><strong>Review abstract:<\/strong><\/h3>\n<p>Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) is a complex multisystem illness that lacks effective therapy and a biomedical understanding of its causes.<\/p>\n<p>Despite a prevalence of approximately 0.2\u20130.4% and its high public health burden, and evidence that it has a heritable component, ME\/CFS has not yet benefited from the advances in technology and analytical tools that have improved our understanding of many other complex diseases.<\/p>\n<p><img data-recalc-dims=\"1\" decoding=\"async\" class=\"alignleft size-medium wp-image-22999 lazyload\" data-src=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/11\/dna-gene.png?resize=300%2C233&#038;ssl=1\" alt=\"\" width=\"300\" height=\"233\" data-srcset=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/11\/dna-gene.png?resize=300%2C233&amp;ssl=1 300w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/11\/dna-gene.png?resize=150%2C116&amp;ssl=1 150w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2019\/11\/dna-gene.png?w=640&amp;ssl=1 640w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/233;\" \/>Here we critically review existing evidence that genetic factors alter ME\/CFS risk before concluding that most ME\/CFS candidate gene associations are not replicated by the larger CFS cohort within UK Biobank. Multiple genome-wide association studies of this cohort also have not yielded consistently significant associations.<\/p>\n<p>Ahead of upcoming larger genome-wide association studies we discuss how these could generate new lines of enquiry into the DNA variants, genes and cell-types that are causally involved in ME\/CFS disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Genetic risk factors of ME\/CFS: a critical review, by in Human Molecular Genetics, ddaa169, 3 Aug 2020 [doi.org\/10.1093\/hmg\/ddaa169] &nbsp; Review abstract: Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) is a complex multisystem illness that lacks effective therapy and a biomedical understanding of &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/genetic-risk-factors-of-me-cfs-a-critical-review\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[5970,1925,5922,5928,6130,4486,543,2667],"class_list":["post-27524","post","type-post","status-publish","format-standard","hentry","category-news","tag-decodeme-study","tag-gene-sequencing","tag-genome-wide-association-study","tag-gwas","tag-joshua-j-dibble","tag-prof-chris-ponting","tag-simon-mcgrath","tag-uk-mecfs-biobank"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-79W","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/27524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=27524"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/27524\/revisions"}],"predecessor-version":[{"id":27537,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/27524\/revisions\/27537"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=27524"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=27524"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=27524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}