{"id":27526,"date":"2020-08-11T06:38:03","date_gmt":"2020-08-11T06:38:03","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=27526"},"modified":"2020-08-11T06:46:05","modified_gmt":"2020-08-11T06:46:05","slug":"mapping-of-pathological-change-in-cfs-using-the-ratio-of-t1-t2-weighted-mri-scans","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/mapping-of-pathological-change-in-cfs-using-the-ratio-of-t1-t2-weighted-mri-scans\/","title":{"rendered":"Mapping of pathological change in CFS using the ratio of T1- &#038; T2-weighted MRI scans"},"content":{"rendered":"<h3><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2213158220302035\" target=\"_blank\" rel=\"noopener noreferrer\">Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans<\/a>, by Kiran Thapaliya, Sonya Marshall-Gradisnik, Don Staines, Leighton Barnden <span style=\"text-decoration: underline;\">in<\/span> <em>NeuroImage: Clinical <\/em>Vol 28, 2020, 102366 [doi.org\/10.1016\/j.nicl.2020.102366]<\/h3>\n<p>&nbsp;<\/p>\n<h3><strong>Research highlights<\/strong><\/h3>\n<ul>\n<li>We showed increased T1w\/T2w in ME\/CFS in contrast to other neurodegenerative diseases.<\/li>\n<li>Higher T1w\/T2w occurred in basal ganglia and white matter tracts.<\/li>\n<li>Increased T1w\/T2w indicates increased myelin and\/or iron levels.<\/li>\n<li>T1w\/T2w regressions vs clinical measures were abnormal in cingulate cortex and white matter foci.<\/li>\n<\/ul>\n<h3><strong>Research abstract:<\/strong><\/h3>\n<p>Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME\/CFS) subjects suffer from a variety of cognitive complaints indicating that the central nervous system plays a role in its pathophysiology.<\/p>\n<p>Recently, the ratio <a href=\"https:\/\/www.radiologymasterclass.co.uk\/tutorials\/mri\/t1_and_t2_images\" target=\"_blank\" rel=\"noopener noreferrer\">T1w\/T2w<\/a> has been used to study changes in tissue myelin and\/or iron levels in neurodegenerative diseases such as multiple sclerosis and schizophrenia.<\/p>\n<p>In this study, we applied the T1w\/T2w method to detect changes in tissue microstructure in ME\/CFS patients relative to healthy controls. We mapped the T1w\/T2w signal intensity values in the whole brain for forty-five ME\/CFS patients who met Fukuda criteria and twenty-seven healthy controls and applied both region- and voxel-based quantification. We also performed interaction-with-group regressions with clinical measures to test for T1w\/T2w relationships that are abnormal in ME\/CFS at the population level.<\/p>\n<p><a href=\"https:\/\/www.brainkart.com\/article\/Region-Based-Analysis_8197\/#:~:text=In%20region-based%20analysis%2C%20a%20program%20is%20viewed%20as,N%20that%20dominates%20all%20the%20nodes%20in%20N.\" target=\"_blank\" rel=\"noopener noreferrer\"><img data-recalc-dims=\"1\" decoding=\"async\" class=\"alignright size-medium wp-image-27545 lazyload\" data-src=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2020\/08\/TW1-TW2-research-basal-ganglia.jpg?resize=287%2C300&#038;ssl=1\" alt=\"\" width=\"287\" height=\"300\" data-srcset=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2020\/08\/TW1-TW2-research-basal-ganglia.jpg?resize=287%2C300&amp;ssl=1 287w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2020\/08\/TW1-TW2-research-basal-ganglia.jpg?resize=143%2C150&amp;ssl=1 143w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2020\/08\/TW1-TW2-research-basal-ganglia.jpg?w=533&amp;ssl=1 533w\" data-sizes=\"(max-width: 287px) 100vw, 287px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 287px; --smush-placeholder-aspect-ratio: 287\/300;\" \/>Region-based analysis<\/a> showed significantly elevated T1w\/T2w values (increased myelin and\/or iron) in ME\/CFS in both white matter (WM) and subcortical grey matter. The <a href=\"https:\/\/en.wikipedia.org\/wiki\/Voxel-based_morphometry\" target=\"_blank\" rel=\"noopener noreferrer\">voxel-based<\/a> group comparison with sub-millimetre resolution voxels detected very significant clusters with increased T1w\/T2w in ME\/CFS, mostly in subcortical grey matter, but also in brainstem and projection WM tracts. No areas with decreased T1w\/T2w were found in either analysis. ME\/CFS T1w\/T2w regressions with heart-rate variability, cognitive performance, respiration rate and physical well-being were abnormal in both gray and white matter foci.<\/p>\n<p>Our study demonstrates that the T1w\/T2w approach is very sensitive and shows increases in myelin and\/or iron in <a href=\"https:\/\/en.m.wikipedia.org\/wiki\/White_matter#:~:text=White%20matter%20refers%20to%20areas%20of%20the%20central,made%20up%20of%20myelinated%20axons%2C%20also%20called%20tracts.\" target=\"_blank\" rel=\"noopener noreferrer\">WM<\/a> and <a href=\"https:\/\/en.wikipedia.org\/wiki\/Basal_ganglia\" target=\"_blank\" rel=\"noopener noreferrer\">basal ganglia<\/a> in ME\/CFS.<\/p>\n<div id=\"k0045\" class=\"keyword\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans, by Kiran Thapaliya, Sonya Marshall-Gradisnik, Don Staines, Leighton Barnden in NeuroImage: Clinical Vol 28, 2020, 102366 [doi.org\/10.1016\/j.nicl.2020.102366] &nbsp; Research highlights We showed increased &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/mapping-of-pathological-change-in-cfs-using-the-ratio-of-t1-t2-weighted-mri-scans\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3495,1249,6135,5872,1037,6134,2676,6131,6133,6132,1246],"class_list":["post-27526","post","type-post","status-publish","format-standard","hentry","category-news","tag-dr-leighton-barnden","tag-dr-sonya-marshall-gradisnik","tag-iron","tag-kiran-thapaliya","tag-mri","tag-myelin","tag-prof-donald-staines","tag-t1-weighted","tag-t1w-t2w-ratio","tag-t2-weighted","tag-white-matter"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-79Y","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/27526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=27526"}],"version-history":[{"count":6,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/27526\/revisions"}],"predecessor-version":[{"id":27550,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/27526\/revisions\/27550"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=27526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=27526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=27526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}