{"id":27992,"date":"2020-09-18T06:56:04","date_gmt":"2020-09-18T06:56:04","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=27992"},"modified":"2020-09-18T06:56:04","modified_gmt":"2020-09-18T06:56:04","slug":"an-analysis-of-2%e2%80%90day-cardiopulmonary-exercise-testing-to-assess-unexplained-fatigue","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/an-analysis-of-2%e2%80%90day-cardiopulmonary-exercise-testing-to-assess-unexplained-fatigue\/","title":{"rendered":"An analysis of 2\u2010day cardiopulmonary exercise testing to assess unexplained fatigue"},"content":{"rendered":"

An analysis of 2\u2010day cardiopulmonary exercise testing to assess unexplained fatigue<\/a>, by Jacob B Lindheimer, Thomas Alexander, Wei Qian, Jacquelyn C Klein\u2010Adams, Gudrun Lange, Benjamin H Natelson, Dane B Cook, Helene Z Hill, Michael J Falvo in<\/span> Physiological Reports,<\/em>\u00a0Vol 8, Issue 17,\u00a0Sep 2020 [doi.org\/10.14814\/phy2.14564]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

\"\"Two consecutive maximal cardiopulmonary exercise tests (CPETs) performed 24 hr apart (2\u2010day CPET protocol<\/a>) are increasingly used to evaluate post\u2010exertional malaise (PEM) and related disability among individuals with myalgic encephalomyelitis\/ chronic fatigue syndrome (ME\/CFS).<\/p>\n

This protocol may extend to other fatiguing illnesses with similar characteristics to ME\/CFS; however, 2\u2010day CPET protocol reliability and minimum change required to be considered clinically meaningful (i.e., exceeding the standard error of the measure) are not well characterized.<\/p>\n

To address this gap, we evaluated the 2\u2010day CPET protocol in Gulf War Illness (<\/a>GWI) by quantifying repeatability of seven CPET parameters, establishing their thresholds of clinically significant change, and determining whether changes differed between veterans with GWI and controls. Excluding those not attaining peak effort criteria (n = 15), we calculated intraclass correlation coefficients (ICCs), the smallest real difference (SRD%), and repeated measures analysis of variance (RM\u2010ANOVA) at the ventilatory anaerobic threshold (VAT) and peak exercise in 15 veterans with GWI and eight controls.<\/p>\n

ICC values at peak ranged from moderate to excellent for veterans with GWI (mean [range]; 0.84 [0.65 \u2013 0.92]) and were reduced at the VAT (0.68 [0.37 \u2013 0.78]). Across CPET variables, the SRD% at peak exercise for veterans with GWI (18.8 [8.8 \u2013 28.8]) was generally lower than at the VAT (28.1 [9.5 \u2013 34.8]). RM\u2010ANOVAs did not detect any significant group\u2010by\u2010time interactions (all p > .05).<\/p>\n

The methods and findings reported here provide a framework for evaluating 2\u2010day CPET reliability, and reinforce the importance of carefully considering measurement error in the population of interest when interpreting findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

An analysis of 2\u2010day cardiopulmonary exercise testing to assess unexplained fatigue, by Jacob B Lindheimer, Thomas Alexander, Wei Qian, Jacquelyn C Klein\u2010Adams, Gudrun Lange, Benjamin H Natelson, Dane B Cook, Helene Z Hill, Michael J Falvo in Physiological Reports,\u00a0Vol 8, … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3049,679,2847,1010,34,845,6203,6207,6204,6202,6206,6205],"class_list":["post-27992","post","type-post","status-publish","format-standard","hentry","category-news","tag-2-day-cpet","tag-cardiopulmonary-exercise-tests","tag-dr-benjamin-natelson","tag-dr-dane-b-cook","tag-dr-gudrun-lange","tag-gulf-war-illness","tag-helene-z-hill","tag-jacob-b-lindheimer","tag-jacquelyn-c-kleinadams","tag-michael-j-falvo","tag-thomas-alexander","tag-wei-qian"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-7hu","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/27992","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=27992"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/27992\/revisions"}],"predecessor-version":[{"id":28049,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/27992\/revisions\/28049"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=27992"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=27992"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=27992"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}