{"id":28281,"date":"2020-10-12T05:29:50","date_gmt":"2020-10-12T04:29:50","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=28281"},"modified":"2020-10-12T05:29:50","modified_gmt":"2020-10-12T04:29:50","slug":"reductions-in-cerebral-blood-flow-can-be-provoked-by-sitting-in-severe-me-cfs-patients","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/reductions-in-cerebral-blood-flow-can-be-provoked-by-sitting-in-severe-me-cfs-patients\/","title":{"rendered":"Reductions in cerebral blood flow can be provoked by sitting in severe ME\/CFS patients"},"content":{"rendered":"

Reductions in cerebral blood flow can be provoked by sitting in severe Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome patients<\/a>,\u00a0by C (Linda) MC van Campen, Peter C Rowe and Frans C Visser in<\/span> Healthcare<\/em> 2020, 8(4), 394 [doi.org\/10.3390\/healthcare8040394]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Introduction:<\/strong><\/p>\n

In a large study with myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) patients, we showed that 86% had symptoms of orthostatic intolerance in daily life and that 90% had an abnormal reduction in cerebral blood flow<\/a> (CBF) during a standard tilt test.<\/p>\n

A standard head-up tilt test might not be tolerated by the most severely affected bed-ridden ME\/CFS patients. Sitting upright is a milder orthostatic stress. The present study examined whether a sitting test, measuring cerebral blood flow by extracranial Doppler<\/a>, would be sufficient to provoke abnormal reductions in cerebral blood flow in severe ME\/CFS patients.<\/p>\n

Methods and results:<\/strong><\/p>\n

100 severe ME\/CFS patients were studied, (88 females) and were compared with 15 healthy controls (HC) (13 females). CBF was measured first while seated for at least one hour, followed by a CBF measurement in the supine position. Fibromyalgia was present in 37 patients. Demographic data as well as supine heart rate and blood pressures were not different between ME\/CFS patients and HC.<\/p>\n

\"\"Heart rate and blood pressure did not change significantly between supine<\/a> and sitting both in patients and HC. Supine CBF was not different between patients and HC. In contrast, absolute CBF during sitting was lower in patients compared to HC: 474 (96) mL\/min in
\npatients and 627 (89) mL\/min in HC; p < 0.0001. As a result, percent CBF reduction while seated was \u221224.5 (9.4)% in severe ME\/CFS patients and \u22120.4 (1.2)% in HC (p < 0.0001).<\/p>\n

In the ten patients who had no orthostatic intolerance complaints in daily life, the CBF reduction was \u22122.7 (2.1)%, which was not significantly different from HC (p =0.58). The remaining 90 patients with orthostatic intolerance complaints had a \u221226.9 (6.2)% CBF reduction.<\/p>\n

No difference in CBF parameters was found in patients with and without fibromyalgia. Patients with a previous diagnosis of postural orthostatic tachycardia syndrome (POTS) had a significantly larger CBF reduction compared with those without POTS: 28.8 (7.2)% vs. 22.3 (9.7)% (p = 0.0008).<\/p>\n

Conclusions:<\/strong><\/p>\n

A sitting test in severe ME\/CFS patients was sufficient to provoke a clinically and statistically significant mean CBF decline of 24.5%. Patients with a previous diagnosis of POTS had a larger CBF reduction while seated, compared to patients without POTS. The magnitude of these CBF reductions is similar to the results in less severely affected ME\/CFS patients during head-up tilt, suggesting that a sitting test is adequate for the diagnosis of orthostatic intolerance in severely affected patients.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Reductions in cerebral blood flow can be provoked by sitting in severe Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome patients,\u00a0by C (Linda) MC van Campen, Peter C Rowe and Frans C Visser in Healthcare 2020, 8(4), 394 [doi.org\/10.3390\/healthcare8040394]   Research abstract: Introduction: In … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[799,798,4006,3591,251,5424,5688,493,492,332,331,36],"class_list":["post-28281","post","type-post","status-publish","format-standard","hentry","category-news","tag-cbf","tag-cerebral-blood-flow","tag-dr-linda-van-campen","tag-dr-peter-rowe","tag-fibromyalgia","tag-frans-c-visser","tag-head-up-tilt-test","tag-oi","tag-orthostatic-intolerance","tag-postural-orthostatic-tachycardia-syndrome","tag-pots","tag-severe-me"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-7m9","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/28281","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=28281"}],"version-history":[{"count":1,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/28281\/revisions"}],"predecessor-version":[{"id":28283,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/28281\/revisions\/28283"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=28281"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=28281"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=28281"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}