{"id":28626,"date":"2020-12-05T19:42:31","date_gmt":"2020-12-05T19:42:31","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=28626"},"modified":"2021-02-19T19:45:44","modified_gmt":"2021-02-19T19:45:44","slug":"systematic-review-of-primary-outcome-measurements-for-cfs-me-in-randomized-controlled-trials","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/systematic-review-of-primary-outcome-measurements-for-cfs-me-in-randomized-controlled-trials\/","title":{"rendered":"Systematic review of Primary Outcome Measurements for CFS\/ME in randomized controlled trials"},"content":{"rendered":"

Systematic review of primary Outcome Measurements for Chronic Fatigue Syndrome\/ Myalgic Encephalomyelitis (CFS\/ME) in randomized controlled trials<\/a>, by\u00a0 Do-Young Kim, Jin-Seok Lee and Chang-Gue Son in<\/span> J. Clin. Med.<\/em> 2020, 9(11) 3463 [doi.org\/10.3390\/jcm9113463] (This article belongs to the Special Issue\u00a0Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis: Diagnosis and Treatment)<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Background: <\/strong><\/p>\n

Due to its unknown etiology, the objective diagnosis and therapeutics of chronic fatigue syndrome\/myalgic encephalomyelitis (CFS\/ME) are still challenging.<\/p>\n

Generally, the patient-reported outcome (PRO) is the major strategy driving treatment response because the patient is the most important judge of whether changes are meaningful.<\/p>\n

Methods: <\/strong><\/p>\n

In order to determine the overall characteristics of the main outcome measurement applied in clinical trials for CFS\/ME, we systematically surveyed the literature using two electronic databases, PubMed and the Cochrane Library, throughout June 2020. We analyzed randomized controlled trials (RCTs) for CFS\/ME focusing especially on main measurements.<\/p>\n

Results: <\/strong><\/p>\n

Fifty-two RCTs out of a total 540 searched were selected according to eligibility criteria. Thirty-one RCTs (59.6%) used single primary outcome and others adapted \u22652 kinds of measurements. In total, 15 PRO-derived tools were adapted (50 RCTs; 96.2%) along with two behavioral measurements for adolescents (4 RCTs; 7.7%). The 36-item Short Form Health Survey (SF-36; 16 RCTs), Checklist Individual Strength (CIS; 14 RCTs), and Chalder Fatigue Questionnaire (CFQ; 11 RCTs) were most frequently used as the main outcomes. Since the first RCT in 1996, Clinical Global Impression (CGI) and SF-36 have been dominantly used each in the first and following decade (26.1% and 28.6%, respectively), while both CIS and Multidimensional Fatigue Inventory (MFI) have been the preferred instruments (21.4% each) in recent years (2016 to 2020).<\/p>\n

Conclusions: <\/strong><\/p>\n

This review comprehensively provides the choice pattern of the assessment tools for interventions in RCTs for CFS\/ME. Our data would be helpful practically in the design of clinical studies for CFS\/ME-related therapeutic development.<\/p>\n","protected":false},"excerpt":{"rendered":"

Systematic review of primary Outcome Measurements for Chronic Fatigue Syndrome\/ Myalgic Encephalomyelitis (CFS\/ME) in randomized controlled trials, by\u00a0 Do-Young Kim, Jin-Seok Lee and Chang-Gue Son in J. Clin. Med. 2020, 9(11) 3463 [doi.org\/10.3390\/jcm9113463] (This article belongs to the Special Issue\u00a0Chronic … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[5335,5576,5339,5369,25,5577,5574],"class_list":["post-28626","post","type-post","status-publish","format-standard","hentry","category-news","tag-chang-gue-son","tag-do-young-kim","tag-jin-seok-lee","tag-patient-reported-outcome-measure","tag-proms","tag-randomised-controlled-trials","tag-rct"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-7rI","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/28626","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=28626"}],"version-history":[{"count":6,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/28626\/revisions"}],"predecessor-version":[{"id":29856,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/28626\/revisions\/29856"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=28626"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=28626"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=28626"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}