{"id":29127,"date":"2020-12-17T07:59:11","date_gmt":"2020-12-17T07:59:11","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=29127"},"modified":"2020-12-17T07:59:11","modified_gmt":"2020-12-17T07:59:11","slug":"potential-causal-factors-of-cfs-me-a-concise-systematic-scoping-review-of-factors-researched","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/potential-causal-factors-of-cfs-me-a-concise-systematic-scoping-review-of-factors-researched\/","title":{"rendered":"Potential causal factors of CFS\/ME: a concise & systematic scoping review of factors researched"},"content":{"rendered":"

Potential causal factors of CFS\/ME: a concise and systematic scoping review of factors researched<\/a>, by \u00a0in<\/span> Journal of Translional Medicine <\/em>vol 18, no: 484 (2020) 14 December 2020<\/h3>\n

 <\/p>\n

Review abstract:<\/strong><\/h3>\n

Background<\/strong>
\nChronic fatigue syndrome\/myalgic encephalomyelitis (CFS\/ME) is understood as a complex condition, likely triggered and sustained by an interplay of biological, psychological, and social factors. Little oversight exists of the field of causal research. This systematic scoping review explores potential causal factors of CFS\/ME as researched by primary studies.<\/p>\n

Methods<\/strong>
\nWe searched eight databases for primary studies that examined potential causal factors of\u00a0CFS\/ME. Based on title\/abstract review, two researchers independently sorted each study\u2019s factors into nine main categories and 71 subordinate categories, using a system developed with input given during a 2018 ME conference, specialists and representatives from a ME patient advocacy group, and using BMJ Best Practice\u2019s description of CFS\/ME etiology. We also extracted data related to study design, size, diagnostic criteria and comparison groups.<\/p>\n

Results<\/strong>
\nWe included 1161 primary studies published between January 1979 and June 2019. Based on title\/abstract analysis, no single causal factor dominated in these studies, and studies reported a mean of 2.73 factors. The four most common factors were: immunological (297 studies), psychological (243), infections (198), and neuroendocrinal (198). The most frequent study designs were case\u2013control studies (894 studies) comparing CFS\/ME patients with healthy participants. More than half of the studies (that reported study size in the title\/abstract)\u00a0included 100 or fewer participants.<\/p>\n

\"\"<\/p>\n

Conclusion<\/strong>
\nThe field of causal hypotheses of CFS\/ME is diverse, and we found that the studies examined all the main categories of possible factors that we had defined a priori. Most studies were not designed to adequately explore causality, rather to establish hypotheses. We need larger studies with stronger study designs to gain better knowledge of causal factors of CFS\/ME.<\/p>\n","protected":false},"excerpt":{"rendered":"

Potential causal factors of CFS\/ME: a concise and systematic scoping review of factors researched, by \u00a0in Journal of Translional Medicine vol 18, no: 484 (2020) 14 December 2020   Review abstract: Background Chronic fatigue syndrome\/myalgic encephalomyelitis (CFS\/ME) is understood as … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[6407,1834,911,5924,6406,2641,6405,6404],"class_list":["post-29127","post","type-post","status-publish","format-standard","hentry","category-news","tag-ashley-elizabeth-muller","tag-biomedical-research","tag-cause","tag-inger-johanne-bakken","tag-kari-tveito","tag-lillebeth-larun","tag-signe-a-flottorp","tag-siri-mjaaland"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-7zN","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/29127","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=29127"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/29127\/revisions"}],"predecessor-version":[{"id":29148,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/29127\/revisions\/29148"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=29127"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=29127"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=29127"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}