{"id":29230,"date":"2021-01-05T21:33:50","date_gmt":"2021-01-05T21:33:50","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=29230"},"modified":"2021-01-05T21:33:50","modified_gmt":"2021-01-05T21:33:50","slug":"are-circulating-fgf21-nt-probnp-promising-novel-biomarkers-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/are-circulating-fgf21-nt-probnp-promising-novel-biomarkers-in-me-cfs\/","title":{"rendered":"Are circulating FGF21 & NT-proBNP promising novel biomarkers in ME\/CFS"},"content":{"rendered":"

Are circulating FGF21 and NT-proBNP promising novel biomarkers in Myalgic Encephalomyelitis\/ Chronic Fatigue Syndrome?<\/a>, by Prof Joan Carles Domingo, Dr Bego\u00f1a Cordobilla, Dr Roser Ferrer, Dr Marina Giralt, Dr Jose Alegre-Martin, and Dr Jesus Castro-Marrero in<\/span> Antioxidants & Redox Signaling,<\/em> 22 Dec 2020 [doi.org\/10.1089\/ars.2020.8230]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

\"\"Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) is a chronic, disabling, and complex multisystem illness of unknown etiology. The protein FGF21<\/a> regulates glucose homeostasis<\/a> and lipid metabolism,<\/a> and the protein NT-proBNP<\/a> is strongly associated with an elevated cardiovascular risk; however, little is known about their role in ME\/CFS patients. To address this gap, we explored the association between FGF21 and NT-proBNP and oxidative stress<\/a> and inflammatory markers<\/a> in ME\/CFS.<\/p>\n

Twenty-one ME\/CFS patients and 20 matched healthy controls were included in the study. Participants filled out validated self-reported questionnaires on their current health status covering demographic and clinical characteristics. Plasma showed significantly decreased total antioxidant capacity and increased lipoperoxides levels (p = 0.009 and p = 0.021, respectively) in ME\/CFS. These ME\/CFS patients also had significantly increased levels of inflammatory cytokines<\/a> (IL-1\u03b2, IL-6, IL-10, TNF-\u03b1, and C-reactive protein (p < 0.05 for all) but not for IL-8 (p = 0.833) in ME\/CFS, indicating low-grade systemic inflammation status.<\/p>\n

Circulating FGF21 and NT-proBNP levels were significantly higher (p < 0.0001 and p = 0.005, respectively) in ME\/CFS patients than in healthy controls. Significantly positive correlations were found between NT-proBNP levels and IL-1\u03b2 and IL-6 (p = 0.04 and p = 0.01) in ME\/CFS patients but not between FGF21 and these cytokines. In contrast, no significant correlations were found for either FGF21 or NT-proBNP in controls.<\/p>\n

These findings lead to the hypothesis that elevated FGF21 and NT-proBNP levels and the association between NT-proBNP and inflammation may be promising novel diagnostic and therapeutic targets in ME\/CFS.<\/p>\n

Read full article<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Are circulating FGF21 and NT-proBNP promising novel biomarkers in Myalgic Encephalomyelitis\/ Chronic Fatigue Syndrome?, by Prof Joan Carles Domingo, Dr Bego\u00f1a Cordobilla, Dr Roser Ferrer, Dr Marina Giralt, Dr Jose Alegre-Martin, and Dr Jesus Castro-Marrero in Antioxidants & Redox Signaling, … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[726,6414,6412,6413,6417,1579,4284,5453,6416,6415,6418],"class_list":["post-29230","post","type-post","status-publish","format-standard","hentry","category-news","tag-biomarkers","tag-dr-begona-cordobilla","tag-dr-marina-giralt","tag-dr-roser-ferrer","tag-glucose-homeostasis","tag-inflammatory-cytokines","tag-jesus-castro-marrero","tag-jose-alegre-martin","tag-lipid-metabolism","tag-prof-joan-carles-domingo","tag-protein-nt-probnp"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-7Bs","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/29230","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=29230"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/29230\/revisions"}],"predecessor-version":[{"id":29253,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/29230\/revisions\/29253"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=29230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=29230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=29230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}