{"id":29285,"date":"2021-01-07T23:36:00","date_gmt":"2021-01-07T23:36:00","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=29285"},"modified":"2021-01-07T23:36:00","modified_gmt":"2021-01-07T23:36:00","slug":"covid-19-cfs-is-the-worst-yet-to-come","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/covid-19-cfs-is-the-worst-yet-to-come\/","title":{"rendered":"COVID-19 & CFS: is the worst yet to come?"},"content":{"rendered":"

COVID-19 and chronic fatigue syndrome: Is the worst yet to come?<\/a> by Peter Wostyn<\/a> in<\/span>\u00a0Med Hypotheses<\/em> 2021 Jan 2 [doi: 10.1016\/j.mehy.2020.110469]<\/h3>\n

 <\/p>\n

Article abstract:<\/strong><\/h3>\n

There has been concern about possible long-term sequelae resembling myalgic encephalomyelitis\/chronic fatigue syndrome in COVID-19 patients. Clarifying the mechanisms underlying such a “post-COVID-19 fatigue syndrome” is essential for the development of preventive and early treatment methods for this syndrome.<\/p>\n

\"\"In the present paper, by integrating insights pertaining to the glymphatic system<\/a> and the nasal cerebrospinal fluid<\/a> outflow pathway with findings in patients with chronic fatigue syndrome, idiopathic intracranial hypertension,<\/a> and COVID-19, I provide a coherent conceptual framework for understanding the pathophysiology of post-COVID-19 fatigue syndrome.<\/p>\n

According to this hypothesis, this syndrome may result from damage to olfactory sensory neurons,<\/a> causing reduced outflow of cerebrospinal fluid through the cribriform plate, and further leading to congestion of the glymphatic system with subsequent toxic build-up within the central nervous system. I further postulate that patients with post-COVID-19 fatigue syndrome may benefit from cerebrospinal fluid drainage by restoring glymphatic transport and waste removal from the brain.<\/p>\n

Obviously, further research is required to provide further evidence for the presence of this post-viral syndrome, and to provide additional insight regarding the relative contribution of the glymphatic-lymphatic system to it. Other mechanisms may also be involved. If confirmed, the glymphatic-lymphatic system could represent a target in combating post-COVID-19 fatigue syndrome.<\/p>\n

Moreover, further research in this area could also provide new insights into the understanding of chronic fatigue syndrome.<\/p>\n","protected":false},"excerpt":{"rendered":"

COVID-19 and chronic fatigue syndrome: Is the worst yet to come? by Peter Wostyn in\u00a0Med Hypotheses 2021 Jan 2 [doi: 10.1016\/j.mehy.2020.110469]   Article abstract: There has been concern about possible long-term sequelae resembling myalgic encephalomyelitis\/chronic fatigue syndrome in COVID-19 patients. … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[877,6422,6421,6423],"class_list":["post-29285","post","type-post","status-publish","format-standard","hentry","category-news","tag-cerebrospinal-fluid","tag-dr-peter-wostyn","tag-glymphatic-system","tag-olfactory-sensory-neuron-damage"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-7Cl","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/29285","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=29285"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/29285\/revisions"}],"predecessor-version":[{"id":29303,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/29285\/revisions\/29303"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=29285"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=29285"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=29285"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}