{"id":29769,"date":"2021-02-15T23:16:12","date_gmt":"2021-02-15T23:16:12","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=29769"},"modified":"2021-02-15T23:16:12","modified_gmt":"2021-02-15T23:16:12","slug":"chronic-covid-19-syndrome-me-cfs-following-the-first-pandemic-wave-in-germany","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/chronic-covid-19-syndrome-me-cfs-following-the-first-pandemic-wave-in-germany\/","title":{"rendered":"Chronic COVID-19 Syndrome & ME\/CFS following the first pandemic wave in Germany"},"content":{"rendered":"

Chronic COVID-19 Syndrome and Chronic Fatigue Syndrome (ME\/CFS) following the first pandemic wave in Germany<\/a> \u2013 a first analysis of a prospective observational study, n<\/span> medRxiv<\/em> 2021.02.06.21249256 [doi.org\/10.1101\/2021.02.06.21249256]\u00a0 This article is a preprint and has not been peer-reviewed<\/em><\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

\"\"Objective:<\/strong><\/p>\n

Characterization of the clinical features of patients with persistent symptoms after mild to moderate COVID-19 infection and exploration of factors associated with the development of Chronic COVID-19 Syndrome (CCS).<\/p>\n

Methods Setting: <\/strong><\/p>\n

Charit\u00e9 Fatigue Center with clinical immunologists and rheumatologist, neurologists and cardiologists at Charit\u00e9 University hospital.<\/p>\n

Participants:<\/strong><\/p>\n

42 patients who presented with persistent moderate to severe fatigue six months following a mostly mild SARS-CoV-2 infection at the Charit\u00e9 Fatigue Center from July to November 2020.<\/p>\n

Main outcome measures: <\/strong><\/p>\n

The primary outcomes were clinical and paraclinical data and meeting diagnostic criteria for Chronic Fatigue Syndrome (ME\/CFS). Relevant neurological and cardiopulmonary morbidity was excluded.<\/p>\n

Results:\u00a0<\/strong><\/p>\n

The median age was 36.5, range 22\u201362, 29 patients were female and 13 male. At six months post acute COVID-19 all patients had fatigue (Chalder Fatigue Score<\/a> median 25 of 33, range 14\u201332), the most frequent other symptoms were post exertional malaise (n=41), cognitive symptoms (n=40), headache (n=38), and muscle pain (n=35). Most patients were moderately to severely impaired in daily life with a median Bell disability score of 50 (range 15\u201390) of 100 (healthy) and Short Form 36<\/a> (SF-36) physical function score of 63 (range 15-80) of 100. 19 of 42 patients fulfilled the 2003 Canadian Consensus Criteria<\/a> for myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS).<\/p>\n

These patients reported more fatigue<\/strong> in the Chalder Fatigue Score (p=0.006), more stress intolerance<\/strong> (p=0.042) and more frequent and longer post exertional malaise<\/strong> <\/a>(PEM) (p=0.003), and hypersensitivity <\/strong>to noise (p=0.029), light (p=0.0143) and temperature (p=0.024) compared to patients not meeting ME\/CFS criteria. Handgrip force<\/strong> was diminished in most patients compared to healthy control values, and lower in CCS\/CFS compared to non-CFS CCS (Fmax1 p=0.085, Fmax2, p=0.050, Fmean1 p=0.043, Fmean2 p=0.034, mean of 10 repeat handgrips, 29 female patients). Mannose-binding lectin (MBL) deficiency<\/strong><\/a> was observed frequently (22% of all patients) and elevated IL-8 levels<\/strong><\/a> were found in 43% of patients.<\/p>\n

Conclusions:<\/strong><\/p>\n

Chronic COVID-19 Syndrome at months 6 is a multisymptomatic frequently debilitating disease fulfilling diagnostic criteria of ME\/CFS in about half of the patients in our study. Research in mechanisms and clinical trials are urgently needed.<\/p>\n","protected":false},"excerpt":{"rendered":"

Chronic COVID-19 Syndrome and Chronic Fatigue Syndrome (ME\/CFS) following the first pandemic wave in Germany \u2013 a first analysis of a prospective observational study, n medRxiv 2021.02.06.21249256 [doi.org\/10.1101\/2021.02.06.21249256]\u00a0 This article is a preprint and has not been peer-reviewed   Research … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[6539,6546,6537,4267,6197,6536,6542,6540,6538,6120,6535,6544,6545,6196,6541,6543],"class_list":["post-29769","post","type-post","status-publish","format-standard","hentry","category-news","tag-b-heidecker","tag-c-kedor","tag-c-skurk","tag-carmen-scheibenbogen","tag-chronic-covid-19","tag-f-paul","tag-f-steinbeis","tag-g-rudolf","tag-hd-volk","tag-helma-freitag","tag-j-bellmann-strobl","tag-k-wittke","tag-l-meyer-arndt","tag-long-covid","tag-m-haffke","tag-t-zoller"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-7K9","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/29769","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=29769"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/29769\/revisions"}],"predecessor-version":[{"id":29806,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/29769\/revisions\/29806"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=29769"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=29769"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=29769"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}