{"id":2997,"date":"2014-04-24T09:03:28","date_gmt":"2014-04-24T09:03:28","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=2997"},"modified":"2014-04-24T09:03:28","modified_gmt":"2014-04-24T09:03:28","slug":"review-of-the-role-of-t-cells-in-the-mecfs-immune-system","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/review-of-the-role-of-t-cells-in-the-mecfs-immune-system\/","title":{"rendered":"Review of the role of T cells in the ME\/CFS immune system"},"content":{"rendered":"<p><strong>Abstract<\/strong><\/p>\n<p>Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis (CFS\/ME) is a multifactorial disorder defined by symptom-specific criteria and characterised by severe and prolonged fatigue. CFS\/ME typically affects a variety of bodily systems, including the immune system.<\/p>\n<p>Patients with CFS\/ME exhibit significantly reduced <a title=\"NK cells\" href=\"https:\/\/en.wikipedia.org\/wiki\/Natural_Killer_cell\" target=\"_blank\">Natural Killer (NK) cell<\/a> activity suggesting immune which may be hallmarks of changes in the adaptive immune system, potentially including T cell subsets and function. The principal purpose of T cells is to regulate immune responses and maintain immune homeostasis.<\/p>\n<p>These regulatory measures can often be compromised during illness and may present in a number of diseases including CFS\/ME. This review paper examines the role of T cells in CFS\/ME and the potential impact of T cells on CFS\/ME immune profiles with an evaluation of the current literature.<\/p>\n<p><strong>Conclusion<\/strong><\/p>\n<p>A number of studies have assessed <a title=\"T cell\" href=\"https:\/\/en.wikipedia.org\/wiki\/T_cell\" target=\"_blank\">T cells<\/a> in CFS\/ME, although further studies are required to obtain consistency and validation of results. Assessment of T cell cytokines in CFS\/ME patients based on <a title=\"PBMC\" href=\"https:\/\/en.wikipedia.org\/wiki\/PBMC\" target=\"_blank\">PBMCs<\/a> is not the most appropriate method of assessing these cells as they are not specific to subsets of T cells that vary in cytokine secretion. Similarly, assessment of CD8 + T and CD4 + T cells and cytokine profiles, may highlight specific cells that may be affected in CFS\/ME patients. In particular, <a title=\"Tregs\" href=\"https:\/\/en.wikipedia.org\/wiki\/Regulatory_T_cell\" target=\"_blank\">Tregs<\/a> and their regulatory activities may deserve closer investigation. Subgrouping of CFS\/ME patients may be necessary in the future to determine whether T cell subsets and function differs among CFS\/ME patients based on their variation of disorder onset or severity.<\/p>\n<p><a title=\"CFS\/ME and the Potential Role of T Cells\" href=\"http:\/\/www.m-hikari.com\/bmgt\/bmgt2014\/bmgt1-4-2014\/hardcastleBMGT1-4-2014.pdf\" target=\"_blank\">Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis and the Potential Role of T Cells <\/a>by\u00a0S. L. Hardcastle, E. W. Brenu(a), D.R. Staines, S. Marshall-Gradisnik <span style=\"text-decoration: underline;\">in<\/span> <em>Biological Markers and Guided Therapy<\/em> Vol 1 2014<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis (CFS\/ME) is a multifactorial disorder defined by symptom-specific criteria and characterised by severe and prolonged fatigue. CFS\/ME typically affects a variety of bodily systems, including the immune system. Patients with CFS\/ME exhibit significantly reduced Natural &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/review-of-the-role-of-t-cells-in-the-mecfs-immune-system\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[383,722,691,613],"class_list":["post-2997","post","type-post","status-publish","format-standard","hentry","category-news","tag-immune-system","tag-natural-killer-cells","tag-nk-cells","tag-t-cells"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-Ml","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/2997","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=2997"}],"version-history":[{"count":1,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/2997\/revisions"}],"predecessor-version":[{"id":2998,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/2997\/revisions\/2998"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=2997"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=2997"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=2997"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}